301907 VO Die Entwicklung von neuen Tumor Immunotherapien (2020W)

Currently, promising results are being achieved in the field of cancer immunotherapy. However, not every patients is responding to the available therapies. The lecture will:
(1) give an overview on current therapies: their potential, their risks and where they currently fail: description of different therapy modalities: Antibodies (check point inhibitors, protacs, T cell engagers , neutralizing Antibodies) and small molecule therapies (inhibitors and agonists)
(2) description on how cancer imrnunotherapy targets are being discovered: available methods for target screening and how to validate them
(3) description how to validate the targets
(4) explain why biomarker research is important for the success oftherapies
(5) describe the different stages of clinical trials