323115 VU NMR for Drug Design - MPS5 (2024S)

Protein-ligand interactions are at the heart of drug discovery research. NMR spectroscopy is perfectly suited to identify and validate protein-ligand interactions. A large number of NMR experiments are available. They are very powerful, but may also have pitfalls and limitations.
In this lecture, we will present central experiments for NMR in drug discovery, and assess their strengths and reliabilities.
Furthermore, methods for subsequent characterization of the interaction such as quantitative KD determination, binding mode analysis, or structure determination will be covered if time allows.