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301101 VO Epigenetics- From basic mechanisms to medical applications (2018W)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

Language: English

Examination dates

Lecturers

Classes

Block: täglich 5.11-23.11. 2018, 16.30 - 18.00 Uhr
im Gr.Histologie/HS, Schwarzspannierstraße 17, 1090 Wien
https://teachingcenter.meduniwien.ac.at/abteilungen/ressourcen-management/raumanfragen-fuer-veranstaltungen-im-hoersaalzentrum/ebene7/


Information

Aims, contents and method of the course

Part Seiser:
1. Introduction
History of Epigenetics
Chromatin composition

2. Basic epigenetic mechanisms
DNA methylation
Histone modification/remodeling
Non-coding RNA

3. Epigenetic Phenomena
Imprinting
X-chromosome inactivation
Position effect variegation/Drosophila Epigenetics (Wolfgang Miller)

4. Techniques to study the epigenome

Part Egger:
1. Epigenetic signatures in development and differentiation
Reprogramming of the epigenome during germ cell formation and after fertilization
The concept of cellular memory (Polycomb- Trithorax)

2. Artificial epigenetic reprogramming
Cloning, induced pluripotent stem cells

3. Influence of the Environment / Epigenetic alterations in disease
Tumor epigenetics
Imprinting defects
Complex disease
Mouse models to study epigenetics

4. Epigenetic therapy

5. Development of epigenetic biomarkers

Assessment and permitted materials

Written exam.

Minimum requirements and assessment criteria

To provide an introduction into basic epigenetic mechanisms and illustrate the role of chromatin for regulating different physiological processes as well as its involvement in disease.

Examination topics

Reading list


Association in the course directory

MGE III-1, MMB IV-2, MMB IV-3, MMB W-2, PhD-MB 3, MMEI III, UF MA BU 01, UF MA BU 04,

Last modified: We 19.08.2020 08:08