Universität Wien

320093 VO Applied Pharmacogenetics (2011W)

2.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Details

Language: German

Examination dates

Lecturers

Classes

Currently no class schedule is known.

Information

Aims, contents and method of the course

Examples of drugs for the treatment of ophthalmic or skin diseases, which will be discussed in the lecture, are as follows:
" Bimatoprost, a Prostaglandin F2 -derivative, travoprost, a full agonist at the
prostaglandin FP-receptor, and brinzolamide, a topically active inhibitor of
carboanhydrase II, are used to lower the intraocular pressure in chronic open-
angle glaucoma and in ocular hypertension
" Verteporphin, a photosensitizer, which is suited for photodynamic therapy of
chorioidal neo-vascularizations
" Temoporphin, another photosensitizer, is applied in the photodynamic tumour-
therapy, for instance in certain cases of precancerous lesions and malignant
tumours of the skin
" Imiquimod is suited for the local therapy of Condylomata acuminata in the genital
and anal regions
" the immunsuppressive agents Pimecrolimus and Tacrolimus are important
additions to the topical treatment of atopic dermatitis
" Eflornithin, an irreversible inhibitor of the ornithin-decarboxylase, which is
registered for the treatment of hirsutism in the face of women

Assessment and permitted materials

Minimum requirements and assessment criteria

This course is intended to provide insights into the methodology of pharmacogenetics.
The pharmacokinetics of many drugs is affected by activity of specific cytochrom-P450-enzymes. Genotyping of test subjects (the course participants) will be performed by analysing genomic DNA. The polymorphism of cytochrom-P450 2D6 concerning a particular mutation will be determined. The therapeutic relevance of Cytochrome P450 polymorphism will be discussed.

Examination topics

Reading list

Association in the course directory

A400

Last modified: We 19.08.2020 08:09