320003 VO Biophysical Pharmaceutical Chemistry (2017W)
Labels
Vorlesungszeiten: Mittwoch und Donnerstag 16:45 - 20:00 Uhr HS 8
08.11.2017 - 14.12.2017Prüfungstermine:
27.09.2017 13.15 Uhr HS 8
08.11.2017 11.30 Uhr HS 8
06.12.2017 11.30 Uhr HS 8
10.01.2018 16.45 Uhr HS 8
07.02.2018 09.45 Uhr HS 8
08.11.2017 - 14.12.2017Prüfungstermine:
27.09.2017 13.15 Uhr HS 8
08.11.2017 11.30 Uhr HS 8
06.12.2017 11.30 Uhr HS 8
10.01.2018 16.45 Uhr HS 8
07.02.2018 09.45 Uhr HS 8
Details
Language: German
Examination dates
Wednesday
10.01.2018
16:45 - 18:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
07.02.2018
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
08.03.2018
18:30 - 20:00
UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Monday
16.04.2018
18:30 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
14.05.2018
11:30 - 13:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
20.06.2018
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
12.07.2018
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Tuesday
14.08.2018
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Tuesday
11.09.2018
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
24.10.2018
16:45 - 18:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
03.12.2018
16:45 - 18:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
14.01.2019
16:45 - 18:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
07.02.2019
09:45 - 11:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
13.03.2019
09:45 - 11:15
UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Thursday
16.05.2019
09:45 - 11:15
UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Tuesday
09.07.2019
09:45 - 11:15
UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Friday
13.09.2019
09:45 - 11:15
UZA2 Hörsaal 7 (Raum 2Z210) 2.OG
Wednesday
13.11.2019
13:15 - 14:45
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
27.01.2020
13:15 - 14:45
UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Thursday
30.04.2020
Thursday
25.06.2020
Friday
24.07.2020
Friday
21.08.2020
Friday
25.09.2020
Tuesday
27.10.2020
Tuesday
01.12.2020
Tuesday
26.01.2021
Friday
19.03.2021
Friday
28.05.2021
Lecturers
Classes (iCal) - next class is marked with N
ACHTUNG: aufgrund von Corona wird ab 30.5. der Prüfungsmodus auf mündlich online geändert
Wednesday
08.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
09.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
15.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
16.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
22.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
23.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
29.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
30.11.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
06.12.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
07.12.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
13.12.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
14.12.
16:45 - 20:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Information
Aims, contents and method of the course
the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)
Assessment and permitted materials
written exam; 4 questions multiple choice (5 points/question), 8 questions text and/or calculations (10 points/question); grades: 0-50 points nicht genügend (5; failed)), 51-63 points genügend (4), 64-76 points befriedigend (3), 77-89 points gut (2), 90-100 points sehr gut (1); duration: 90 minutes; allowed material: simple calculator
Minimum requirements and assessment criteria
The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.
Examination topics
Language: German (material partly in English); powerpoint presentation, software demonstrations, material in Moodle
Reading list
Association in the course directory
A210
Last modified: Sa 02.04.2022 00:27