270093 SE Aspects of Bioorganometallic Chemistry (2024W)

In living systems, transition metal complexes provide the active centers of several enzymes (“metalloenzymes”) which catalyze important reactions like 2H+/H2 conversion ([FeFe] and [NiFe] hydrogenases), nitrogen fixation (nitrogenases), interconversion of CO2 and CO by the CO-dehydrogenase and methylation of CO by the acetyl CoA synthase. These metalloenzymes are characterized by the fact that they exhibit a transition metal-carbon bond or are forming a metal-carbon bond during the activation of the substrate. This course is offered as a supplement to the lecture “Bioinorganic Chemistry”.