270193 VO Pharmaceutical and solution chemistry of (metallo)drugs (2020S)
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An/Abmeldung
Hinweis: Ihr Anmeldezeitpunkt innerhalb der Frist hat keine Auswirkungen auf die Platzvergabe (kein "first come, first served").
Details
Sprache: Englisch
Prüfungstermine
Lehrende
Termine
All lectures will take place in lecture room 4, Währinger Straße 42, Halbstock. 03.06., 10.00-12.00, 04.06., 14.00-16.00, 16.06. 10.00-12.00, 17.06., 10.00-12.00, 23.06., 10.00-12.00, 24.06., 10.00-12.00, 25.06., 10.00-12.00, 30.06., 10.00-12.00
Information
Ziele, Inhalte und Methode der Lehrveranstaltung
Art der Leistungskontrolle und erlaubte Hilfsmittel
Mindestanforderungen und Beurteilungsmaßstab
Prüfungsstoff
Literatur
Medicinal Chemistry: Principles and Practice (Ed. F.D. King), Royal Society of Chemistry, 2002.; M.T. Beck; I. Nagypál; Chemistry of Complex Equilibria, Ellis Horwood, Chichester, UK, 1990; Metallotherapeutic Drugs and Metal-based Diagnostic Agents (Eds, M. Gielen, E.R.T. Tiekink), Wiley, Chichester, 2005.
Zuordnung im Vorlesungsverzeichnis
EF-1, EF-2, EF-3
Letzte Änderung: Mi 19.08.2020 07:49
Factors affecting pharmacokinetics (LADME properties: liberation, absorption, distribution, metabolism, excretion), bioavailability, accumulation, biofluids; routes of drug administration. Acid-base properties: macroconstants and microscopic proton dissociation constants. Lipophilicity, solubility and their modifications. Experimental determination of pKa and logP values. Biological pH-buffers.
Metal containing drugs (anticancer/-bacterial/-diabetic; chelate therapy). Solution stability of metal complexes, complex formation equilibrium processes. Conditional stability constants. Concentration distribution. Experimental determination of stability constants. Lipophilicity of metal complexes. Redox properties of metal complexes.
Prodrugs (metallic, nonmetallic).
Effect of interaction with biological macromolecules (proteins, DNA) on pharmacokinetics. Plasma protein binding. Experimental determination of binding sites and binding constants of protein-ligand adducts.