270320 VO Pharmaceutical and solution chemistry of (metallo)drugs (2022W)
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Hinweis: Ihr Anmeldezeitpunkt innerhalb der Frist hat keine Auswirkungen auf die Platzvergabe (kein "first come, first served").
Details
Sprache: Englisch
Prüfungstermine
Lehrende
Termine
03.11. 14-16 SR3
04.11. 14-16 Hörsaal 4
08.11. 16-18 Hörsaal 4
09.11. 14-16 Hörsaal 4
10.11. 12-14 SR4
15.11. 15-17 SR3
16.11. 14-16 Hörsaal 4
17.11. 12-14 Seminar Raum 4
22.11. 15-17 Seminar Raum 3
Information
Ziele, Inhalte und Methode der Lehrveranstaltung
Art der Leistungskontrolle und erlaubte Hilfsmittel
Mindestanforderungen und Beurteilungsmaßstab
Prüfungsstoff
Literatur
Medicinal Chemistry: Principles and Practice (Ed. F.D. King), Royal Society of Chemistry, 2002.; M.T. Beck; I. Nagypál; Chemistry of Complex Equilibria, Ellis Horwood, Chichester, UK, 1990; Metallotherapeutic Drugs and Metal-based Diagnostic Agents (Eds, M. Gielen, E.R.T. Tiekink), Wiley, Chichester, 2005.
Zuordnung im Vorlesungsverzeichnis
EF-1, EF-2, EF-3
Letzte Änderung: Mi 30.11.2022 16:49
Factors affecting pharmacokinetics (LADME properties: liberation, absorption, distribution, metabolism, excretion), bioavailability, accumulation, biofluids; routes of drug administration. Acid-base properties: macroconstants and microscopic proton dissociation constants. Lipophilicity, solubility and their modifications. Experimental determination of pKa and logP values. Biological pH-buffers.
Metal containing drugs (anticancer/-bacterial/-diabetic; chelate therapy). Solution stability of metal complexes, complex formation equilibrium processes. Conditional stability constants. Concentration distribution. Experimental determination of stability constants. Lipophilicity of metal complexes. Redox properties of metal complexes.
Prodrugs (metallic, nonmetallic).
Effect of interaction with biological macromolecules (proteins, DNA) on pharmacokinetics. Plasma protein binding. Experimental determination of binding sites and binding constants of protein-ligand adducts.