Universität Wien FIND

300308 VO Human Evolutionary Genetics: genomic, genes, diseases (2018S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

An/Abmeldung

Details

Sprache: Englisch

Prüfungstermine

Lehrende

Termine (iCal) - nächster Termin ist mit N markiert

Dienstag 06.03. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 13.03. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 20.03. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 10.04. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 17.04. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 24.04. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 08.05. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 15.05. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 29.05. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 05.06. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 12.06. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Dienstag 19.06. 16:00 - 17:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG

Information

Ziele, Inhalte und Methode der Lehrveranstaltung

The aim of this lecture is to provide students with knowledge and understanding of the scientific fields of human genetics, genomics and evolutionary genetics. This lecture will prepare students to understand how genetics, genomics and evolutionary genetics can be utilised to elucidate human phenotypic traits such as human diseases, host defence and behaviours.
The first part of this lecture introduces students to the structure of the human genome, the key aspects of human chromosome biology, human autosomal, mtDNA and X/Y-linked inheritance, gene functions and gene regulation and epigenetics. In the second part students will be briefly introduced to the state-of-the-art methods used in genomics and genetics. The third part of this lecture aims to provide an understanding of the concepts of human evolutionary genetics, population genetics, and anthropological genetics. Students will gain insights how various evolutionary processes (e.g., natural selection, sexual selection, genetic drift, mutation, recombination, and migration) influence human genomic diversity. In the fourth part students will gain knowledge that is required to understand how genomic variation can contribute to phenotypic variation. In this part, there will be an emphasis on immunogenetics and human diseases and on neurogenetics and human behaviours (research-focused lectures providing case-studies). Student will gain understanding how genomic variation can directly or indirectly affect the risk to develop diseases, contribute to host defence, and influences human behaviours.

Teaching and learning methods: Lectures, handouts, and presentations (PowerPoint slides will be provided on Moodle).

Art der Leistungskontrolle und erlaubte Hilfsmittel

Written exam. Scientific (pocket) calculator.

Mindestanforderungen und Beurteilungsmaßstab

Student should gain knowledge and understanding:
i) human genomic structure and variation;
ii) human chromosome biology and heredity;
iii) gene function, regulation, and transcription;
iv) the role of epigenetic modification in genomic regulation;
v) methods used to study human genomes and genes;
vi) the theoretical and analytical methods used in evolutionary genetics, population genetics and anthropological genetics;
vii) how genomic variation can contribute to the variation of human phenotypic traits (diseases, host defense, behaviors);
viii) applying the gained knowledge to research questions/problems.

Prüfungsstoff

Lectures, handouts, and presentations.

Literatur

Human Evolutionary Genetics
Mark A. Jobling, Edward Hollox , Mathew Hurles, Toomas Kivisild, Chris Tyler-Smith.
Publication Date: June 25, 2013 | ISBN-10: 0815341482 | ISBN-13: 978-0815341482 | Edition: 2.

Human Molecular Genetics (4th ed.)
Tom Strachan & Andrew Read
Publication Date: April 2, 2010 | ISBN-10: 0815341490 | ISBN-13: 978-0815341499 | Edition: 4.

The Princeton Guide to Evolution
Jonathan B. Losos (editor in chief), David A. Baum, Douglas J. Futuyma, Hopi E. Hoekstra, Richard E. Lenski, Allen J. Moore, Catherine L. Peichel, Dolph Schluter & Michael C. Whitlock (editors). Publication Date: 2013, ISBN: 9780691149776. eBook ISBN: 9781400848065.

Online Genetics Education Resources: https://www.genome.gov/10000464/online-genetics-education-resources/
Human Genome Resources: https://www.ncbi.nlm.nih.gov/genome/guide/human/
Online Mendelian Inheritance in Man: https://www.omim.org/
Ensembl genome browser: http://www.ensembl.org/index.html

Journal Articles:
Investigative Genetics 20156:6. Genome-wide insights into the genetic history of human populations. https://investigativegenetics.biomedcentral.com/articles/10.1186/s13323-015-0024-0

Nature. 2010 (467):1061-73 | doi:10.1038/nature09534. A map of human genome variation from population-scale sequencing.

Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713). pii: 20150484.Human evolution: a tale from ancient genomes. Llamas, Willerslev, Orlando.

Curr Opin Genet Dev. 2015 Dec; 35: 9–15. The Evolution of the Human Genome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695266/

Zuordnung im Vorlesungsverzeichnis

B-BAN 4, UF BU 10, BAN 2

Letzte Änderung: Do 05.09.2019 12:58