301101 VO Epigenetics- From basic mechanisms to medical applications (2024W)

Die Vorlesung gibt eine Einführung in die grundlegenden Mechanismen der Epigenetik und erklärt die Funktion von epigentischen Mechanismen in verschiedenen physiologischen und Entwicklungs-Prozessen und ihre Wichtigkeit in Krebs und anderen Krankheiten. 1. IntroductionHistory of Epigenetics 2. Basic epigenetic mechanismsDNA methylationChromatin modificationsNon-coding RNARNA methylationEpitranscriptomics3. Epigenetic PhenomenaImprintingX-Chromosome inactivationPosition effect variegation/Drosophila Epigenetics 4. Techniques to study the epigenome5. Epigenetic signatures in development and differentiationReprogramming of the epigenome during germ cell formation and after fertilizationThe concept of cellular memory (Polycomb- Trithorax)6.Influence of the Environment / Epigenetic alterations in diseaseCancer epigenetics, Clinical implications Imprinting defectsComplex diseaseMouse models to study epigenetics7.Selfish genetic elements and the origin of epigenetic mechanisms8. Epigenetics in host-microbe interactions.