Universität Wien FIND

301450 VO Makromolekulare Kristallographie (2019S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

An/Abmeldung

Details

Sprache: Englisch

Prüfungstermine

Lehrende

Termine

Lectures of Macromolecular crystallography will be according to this schedule:

Date Day Time

09.04.19 TUE 16-19
10.04.19 WED 15-18
11.04.19 THU 16-19
12.04.19 FR 16-19
EASTER HOLIDAYS

29.04.19 MO 15-18
30.04.19 TUE 16-19

02.05.19 THU 16-19
03.05.19 FR 16-19

07.05.19 TUE 16-19
08.05.19 WED 15-18
09.05.19 THU 16-19
10.05.19 FR 16-19

14.05.19 TUE 16-19
15.05.19 WED 15-18
16.05.19 THU 16-19
17.05.19 FR 16-19
In the Seminar room of Dept. Structural and Computational Biology, Campus Vienna Biocenter /5, 1030 Wien.


Information

Ziele, Inhalte und Methode der Lehrveranstaltung

The following topics will be covered the major topic of macromolecular crystallography and will provide students with a comprehensive overview of all the steps required to generate a three-dimensional structural information on biological macromolecules:

* sources of X-rays

* crystallisation techniques

* symmetry (point groups, space groups), unit cell, Bravais lattice

* scattering of X-rays, atomic form factor, structure factor

* waves, diffraction of molecules and crystals, Fourier transform; electron density

* set-up of MX diffraction experiment and detectors

* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion

* density modification techniques

* structure refinement, structure validation and analysis

Art der Leistungskontrolle und erlaubte Hilfsmittel

Oral or written exam, depending on the number of students.

Mindestanforderungen und Beurteilungsmaßstab

Prüfungsstoff

Literatur


Zuordnung im Vorlesungsverzeichnis

MMB II-2, MMB W-2, MMEI III, CHE II-6

Letzte Änderung: Di 05.11.2019 10:28