330029 VO Ernährung und Gen Regulation (2009W)
Labels
Regular attendance is required during the course.
Details
max. 30 Teilnehmer*innen
Sprache: Englisch
Lehrende
Termine
Zur Zeit sind keine Termine bekannt.
Information
Ziele, Inhalte und Methode der Lehrveranstaltung
Art der Leistungskontrolle und erlaubte Hilfsmittel
Assessment is based on the following activities:
1. Oral or written presentations of students after the course
2. Activity during the course
Oral presentations: Power point presentations, approximately 15-20 minutes, minimum 5 slides, maximum 10 slides
Written works: 15-20 pages of A4 sheets
Structure: Introduction, discussion, summary.
References, literature: Accepted bibliographical reference data of per reviewed journals or registered scientific meetings should be given. Recent references dated from the last few years are preferred.
1. Oral or written presentations of students after the course
2. Activity during the course
Oral presentations: Power point presentations, approximately 15-20 minutes, minimum 5 slides, maximum 10 slides
Written works: 15-20 pages of A4 sheets
Structure: Introduction, discussion, summary.
References, literature: Accepted bibliographical reference data of per reviewed journals or registered scientific meetings should be given. Recent references dated from the last few years are preferred.
Mindestanforderungen und Beurteilungsmaßstab
Aims:
Giving some relevant examples on the involvement of nutritional factors in genetic regulation,
by showing recent trends in genomics and systems biology
Showing the different, publicly available scientific databases of genomics and proteomics for further studies,
Promoting the presentations of students ¿ own scientific works, related to these fields.
Giving some relevant examples on the involvement of nutritional factors in genetic regulation,
by showing recent trends in genomics and systems biology
Showing the different, publicly available scientific databases of genomics and proteomics for further studies,
Promoting the presentations of students ¿ own scientific works, related to these fields.
Prüfungsstoff
Methods:
1. Lectures on the topics listed above
2. Online presentations of internet-based genomic and proteomic databases
3. Students ¿ presentations on connected topics with common discussions
1. Lectures on the topics listed above
2. Online presentations of internet-based genomic and proteomic databases
3. Students ¿ presentations on connected topics with common discussions
Literatur
Literature:
1. Power point presentations of the lectures will be available
2. Further publications (textbooks and/or review articles) on the topics of genetics, genomics and nutrition/nutritional genomics
1. Power point presentations of the lectures will be available
2. Further publications (textbooks and/or review articles) on the topics of genetics, genomics and nutrition/nutritional genomics
Zuordnung im Vorlesungsverzeichnis
Letzte Änderung: Mo 07.09.2020 15:44
First, the 50 years` history of modern genetics from the double-helix to the Human Genome Project will be reviewed, together with general aspects of gene regulation. Within this, the main general characteristics of chromosomal, monogenic and multifactorial diseases will be discussed first, with special interest to monogenic inherited disorders of metabolism and the common complex diseases with significant environmental/lifestyle effects.
Some metabolic characteristics of typical chromosomal disorders like 21-trisomies as well as those Mendelian disorders which are preventable with diet e.g. phenylketonuria, galactosaemia etc. will be discussed in more details.
The different roles of individual SNP variations and of haplotype variations in genetic regulation, gene expression, transcription and translation will be discussed in details with special regards to complex, widely occurring diseases, e.g. allergic disorders and cardiovascular diseases. Because of the growing impact of nutritional genomics, these new aspects of complex multifactorial diseases will also be mentioned. Examples: Coronary heart disease and related subjects e.g. diabetes, obesity etc. as main health-related challenges.
The genomic-proteomic-metabolic regulatory complex will be reviewed through the scope of applied genomics, nutritional genomics, biological networks and systems biology approach.
Introduction and practical tools for the use of internet-based genetic, genomic and proteomic databases: e.g. OMIM, NCBI-Entrez integrated database, BLAST, Swissprot, PFAM, E-Ensembl will also be shown, with special regards to information technology, nutrition and gene-regulation.
Specific food allergens, GMO food issues will be discussed in the context of food safety issues and genomics.
Besides the topics of epigenetic regulation and nutrition, some interesting new aspects of the post-genomic era, e.g. fractogeometry will also be discussed.
Finally special aspects of nutrition and gene regulation in humans during pregnancy and after birth will be discussed. Some examples: Role of folic acid, vitamin D and probiotic supplementation.
Students ¿ presentations, summary and conclusions will close the program.