Universität Wien

200089 SE Advanced Seminar: Clinical Psychology and Health Psychology (A) (2023S)

Randomisierte Studien in der Evaluation psychologischer Interventionen

4.00 ECTS (2.00 SWS), SPL 20 - Psychologie
Continuous assessment of course work

Vertiefungsseminare können nur für das Pflichtmodul B verwendet werden! Eine Verwendung für das Modul A4 Freie Fächer ist nicht möglich.
Moodle

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

max. 20 participants
Language: German

Lecturers

Classes (iCal) - next class is marked with N

1. Introduction: Hierarchy of evidence – from single case studies to RCTs; PICO questions; selecting an RCT to use in this seminar
2. Designing trials that are fit for purpose: Pragmatic (effectiveness) versus explanatory (efficacy) trials [reading material: Thorpe 2009; Loudon 2015; precis-2.org]
3. Trial design; randomisation, allocation concealment, and blinding [Moher 2010, items 8-11, Box 2-4; consort-statement.org]
4. Whom is this trial about? Sample size, the intention-to-treat principle, per-protocol analysis, and dealing with missing data [Moher 2010, item 7, Fig 1, Box 6]
5. Replicability of interventions: manuals, treatment fidelity, therapist effects [Boutron 2017; Hawe 2004; Hoffmann 2014; Waltz] 1993; What is an appropriate control group? [Gold 2015; Wampold 2015]
6. Clinical outcomes, surrogate outcomes, and biomarkers
7. Appropriate and replicable statistical analysis
9-11. Presentations by students
12. Meta-analysis, risk of bias assessment, grading the evidence; any remaining topics and questions [Higgins 2022, Chapter 8]

Tuesday 07.03. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 14.03. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 21.03. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 28.03. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 18.04. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 09.05. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 16.05. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 23.05. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 06.06. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 13.06. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Tuesday 20.06. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5
Prominentenzimmer Hauptgebäude, Tiefparterre Hof 4
Tuesday 27.06. 16:45 - 18:15 Hörsaal H Psychologie KG Liebiggasse 5

Information

Aims, contents and method of the course

Randomised controlled trials (RCTs) are generally regarded as the gold standard in the evaluation of health-related interventions. If conducted appropriately, they can provide more reliable evidence of intervention effects than any other research design. However, conducting high-quality RCTs of psychological interventions is particularly difficult for several reasons. These include the difficulty of conducting interventions in a consistent way across intervention providers and participants (treatment fidelity); the difficulty of blinding participants, intervention providers, and outcome assessors; and the difficulty of finding an appropriate control or comparison intervention. In contrast to pharmacological development, where the need for regulatory approval imposes additional pressure towards rigorous trial design, conduct, and reporting, the lack of a corresponding process in psychological interventions may contribute further to an imbalance in methodological rigour.
This seminar provides you with an overview of methodological considerations when designing, conducting, analysing and reporting RCTs of psychological interventions. You will find and use (at least) one RCT in an area of your interest and apply these methodological considerations to that trial. At the end of this seminar, you will be able to critically appraise the methodological quality of RCTs of psychological interventions, and you will also have the basic knowledge needed for designing such RCTs yourself.

Assessment and permitted materials

Oral presentations, written assignments, participation.
Regular attendance at the seminar sessions (min. 80%) is a prerequisite for successful completion of the seminar.

Minimum requirements and assessment criteria

Comfortable with reading scientific literature in English; some knowledge of statistics.

Examination topics

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Reading list

Boutron, I., Altman, D. G., Moher, D., Schulz, K. F., Ravaud, P., & Grp, C. N. (2017). CONSORT Statement for Randomized Trials of Nonpharmacologic Treatments: A 2017 Update and a CONSORT Extension for Nonpharmacologic Trial Abstracts. Ann Intern Med, 167(1), 40-+. https://doi.org/10.7326/M17-0046
Gold, C. (2015). Quantitative psychotherapy outcome research: Methodological issues. In O. C. G. Gelo, A. Pritz, & B. Rieken (Eds.), Psychotherapy Research: Foundations, Process, and Outcome (pp. 537–558). Springer. https://doi.org/10.1007/978-3-7091-1382-0_26
Hawe, P., Shiell, A., & Riley, T. (2004). Complex interventions: How ”out of control” can a randomised trial be? BMJ, 328, 1561–1563.
Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (2022). Cochrane Handbook for Systematic Reviews of Interventions (version 6.3, updated February 2022). https://training.cochrane.org/handbook
Hoffmann, T. C., Glasziou, P. P., Boutron, I., Milne, R., Perera, R., Moher, D., Altman, D. G., Barbour, V., Macdonald, H., Johnston, M., Lamb, S. E., Dixon-Woods, M., McCulloch, P., Wyatt, J. C., Chan, A. W., & Michie, S. (2014). Better reporting of interventions: Template for intervention description and replication (TIDieR) checklist and guide. BMJ, 348, g1687. https://doi.org/10.1136/bmj.g1687
Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., & Zwarenstein, M. (2015). The PRECIS-2 tool: Designing trials that are fit for purpose. BMJ, 350. https://doi.org/10.1136/bmj.h2147
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010). CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c869. https://doi.org/10.1136/bmj.c869
Thorpe, K. E., Zwarenstein, M., Oxman, A. D., Treweek, S., Furberg, C. D., Altman, D. G., Tunis, S., Bergel, E., Harvey, I., Magid, D. J., & Chalkidou, K. (2009). A pragmatic-explanatory continuum indicator summary (PRECIS): A tool to help trial designers. Journal of Clinical Epidemiology, 62, 464–475. https://doi.org/10.1016/j.jclinepi.2008.12.011
Waltz, J., Addis, M. E., Koerner, K., & Jacobson, N. S. (1993). Testing the integrity of a psychotherapy protocol: Assessment of adherence and competence. J Consult Clin Psychol, 61(4), 620–630. https://doi.org/10.1037/0022-006X.61.4.620
Wampold, B. E., & Imel, Z. E. (2015). The great psychotherapy debate: The evidence for what makes psychotherapy work (2nd ed.). Routledge.

Association in the course directory

Last modified: Fr 16.06.2023 11:47