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270047 VO From Synthesis to the Science and Strategy of Medicinal Chemistry (2025W)
Labels
Registration/Deregistration
Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).
Details
Language: English
Lecturers
Classes
Currently no class schedule is known.
Information
Aims, contents and method of the course
Assessment and permitted materials
Students will be examined via a 2 hour exam at the completion of the course. Attendence of the six lectures is highly recommended.
Minimum requirements and assessment criteria
Participation in and submission of the final exam is mandatory
Examination topics
1. The thermodynamics of drug-target binding
2. The importance of water
3. Molecular interactions
4. Medicinal chemistry rules of thumb
5. Drug design strategies
6. Design of drug molecules
2. The importance of water
3. Molecular interactions
4. Medicinal chemistry rules of thumb
5. Drug design strategies
6. Design of drug molecules
Reading list
Hunter, Christopher A. "Quantifying intermolecular interactions: guidelines for the molecular recognition toolbox." Angewandte Chemie International Edition 43.40 (2004): 5310-5324.
Bissantz, Caterina, Bernd Kuhn, and Martin Stahl. "A medicinal chemist’s guide to molecular interactions." Journal of medicinal chemistry 53.14 (2010): 5061-5084
McConnell, Darryl B. "Biotin’s lessons in drug design." Journal of Medicinal Chemistry 64.22 (2021): 16319-16327.
Bissantz, Caterina, Bernd Kuhn, and Martin Stahl. "A medicinal chemist’s guide to molecular interactions." Journal of medicinal chemistry 53.14 (2010): 5061-5084
McConnell, Darryl B. "Biotin’s lessons in drug design." Journal of Medicinal Chemistry 64.22 (2021): 16319-16327.
Association in the course directory
CH-SYN-02, CH-WAHL, CH-FE, BC-WAHL, Transferable Skills
Last modified: Fr 27.06.2025 00:02
1. Classes of small molecule drugs an introduction
2. Classes of drug targets an introduction
3. The thermodynamics of drug-target binding
4. The importance of water
5. Molecular interactions – up close & personal
6. Drug design strategies & medicinal chemistry rules of thumb
7. An introduction to finding hits in the vastness of chemical space
Further topics in medicinal chemistry that will not be covered in the course are (1) optimization of cellular and in vivo efficacy, (2) selectivity and toxicity, (3) drug distribution, metabolism and pharmacokinetics