Universität Wien
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270107 VO Stereoselective Drug Analysis (and clinical applications) (2008W)

1.50 ECTS (1.00 SWS), SPL 27 - Chemie

Institut f. Analytische Chemie, Seminarraum (2. Stock)
Zeit: 4.11., 5.11., 11.11., 12.11., 13.11., und 18.11.2008 (jeweils von 18:00 - 19:30)

Details

Language: German

Lecturers

Classes

Currently no class schedule is known.

Information

Aims, contents and method of the course

Content: Basic principles of stereochemistry (nomenclature, chiral elements); Impact of stereochemistry on biological action; Stereochemistry of drug-protein interaction; Stereo-selectivity in pharmacodynamics; Stereoselectivity in pharmacokinetics including pharmacogenetics; Concepts of enantiomer separation; Indirect liquid chromatographic enantiomer separation; Enantioselective capillary electrophoresis (CE) and chiral selectors for CE; Direct liquid chromatographic enantiomer separation including discussion of chiral stationary phases; Gas chromatographic enantiomer separation; Applications of enantiomer separation methods.
Supporting material: Slides of presentation

Assessment and permitted materials

Minimum requirements and assessment criteria

Principles of stereochemistry, impact on biological action

Examination topics

Evaluation: oral examination

Reading list

The Impact of Stereochemistry on Drug Development and Use. H. Y.
Aboul-Enein, I.W. Wainer (Eds.), J. Wiley, New York, 1997.
Recent developments in liquid chromatographic enantioseparation.
M. Lämmerhofer, W. Lindner
In: Handbook of analytical separations, Vol. 1 (Separation methods in
drug synthesis and purification), Elsevier, Amsterdam, 337-437
Separation of enantiomers: needs, challenges, perspectives.
N. M. Maier, P. Franco, W. Lindner
J. Chromatogr. A, 906 (1-2), 3-33.
Stereoselective chromatographic methods for drug analysis.
N. M. Maier, W. Lindner
In: Methods and Principles in Medicinal Chemistry, Vol. 33, 189-260.
Chiral Chromatography.
Michael Laemmerhofer, topic owner/topic chapter in:CHROMEDIA - A web
Infotope for the Practicing Chromatography Community (peer reviewed web
communication). http://www.chromedia.nl/

Association in the course directory

AN-1/CHE II-1

Last modified: Fr 31.08.2018 08:55