270193 VO Pharmaceutical and solution chemistry of (metallo)drugs (2019S)
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Details
Language: English
Examination dates
Lecturers
Classes (iCal) - next class is marked with N
Tuesday
04.06.
15:00 - 17:00
Seminarraum 2 Währinger Straße 38 Dekanat 1. Stock
Wednesday
05.06.
13:30 - 15:00
Hörsaal 4 Chemie HP Währinger Straße 42
Friday
07.06.
09:00 - 11:00
Seminarraum 4 Institut Physikalische Chemie HP Währinger Straße 42
Tuesday
18.06.
13:30 - 15:00
Hörsaal 4 Chemie HP Währinger Straße 42
Wednesday
19.06.
10:00 - 12:00
Seminarraum 4 Institut Physikalische Chemie HP Währinger Straße 42
Tuesday
25.06.
15:00 - 17:00
Seminarraum 2 Währinger Straße 38 Dekanat 1. Stock
Wednesday
26.06.
14:00 - 16:00
Seminarraum 2 Währinger Straße 38 Dekanat 1. Stock
Thursday
27.06.
09:00 - 11:00
Seminarraum 2 Währinger Straße 38 Dekanat 1. Stock
Information
Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
Examination topics
Reading list
Medicinal Chemistry: Principles and Practice (Ed. F.D. King), Royal Society of Chemistry, 2002.; M.T. Beck; I. Nagypál; Chemistry of Complex Equilibria, Ellis Horwood, Chichester, UK, 1990; Metallotherapeutic Drugs and Metal-based Diagnostic Agents (Eds, M. Gielen, E.R.T. Tiekink), Wiley, Chichester, 2005.
Association in the course directory
EF-1, EF-2, EF-3
Last modified: Mo 07.09.2020 15:42
Factors affecting pharmacokinetics (LADME properties: liberation, absorption, distribution, metabolism, excretion), bioavailability, accumulation, biofluids; routes of drug administration. Acid-base properties: macroconstants and microscopic proton dissociation constants. Lipophilicity, solubility and their modifications. Experimental determination of pKa and logP values. Biological pH-buffers.
Metal containing drugs (anticancer/-bacterial/-diabetic; chelate therapy). Solution stability of metal complexes, complex formation equilibrium processes. Conditional stability constants. Concentration distribution. Experimental determination of stability constants. Lipophilicity of metal complexes. Redox properties of metal complexes.
Prodrugs (metallic, nonmetallic).
Effect of interaction with biological macromolecules (proteins, DNA) on pharmacokinetics. Plasma protein binding. Experimental determination of binding sites and binding constants of protein-ligand adducts.