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270218 VO Nucleoside and Nucleic Acid Chemistry (2021W)

3.00 ECTS (2.00 SWS), SPL 27 - Chemie

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

max. 15 participants
Language: German

Lecturers

Classes

Every wednesday morning, digitally (lectures will be recorded and available on Moodle too)

9 am - 10 am

First Lecture: 13/10
Then:
20/10
27/10
03/11
10/11
17/11
24/11
01/12
08/12


Information

Aims, contents and method of the course

The lecture will focus on the structural and synthetic aspects of the chemistry of nucleic acids and of the building blocks of life, nucleosides and nucleotides. We will study the different molecular components of nucleosides: sugar, nucleobases, phosphodiesters all the way up to the structure of nucleic acids, in their single-stranded and double-stranded forms. This will allow us to understand how chemists came up with synthetic methods to produce nucleosides and nucleic acids and how they brought about chemical modifications too. We will discuss in which therapeutical context chemical modifications to nucleosides and nucleic acids are relevant, where they can be introduced and what their effects are. We will briefly talk about the biosynthesis of nucleosides and nucleic acids. Finally, a large portion of the lecture will be dedicated to modern methods for DNA and RNA synthesis.

This is the more chemistry-oriented counterpart of the lecture "Nucleic Acid Biotechnology", available in the Summer Semester.

Assessment and permitted materials

Final Examination at the end of the semester (in English)

Minimum requirements and assessment criteria

Examination topics

Reading list


Association in the course directory

CHE-II 4, CHE II-8, BC-4

Last modified: Tu 21.09.2021 17:09