270316 VO From Synthesis to the Science and Strategy of Medicinal Chemistry (2024W)
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Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).
Details
Information
Aims, contents and method of the course
Assessment and permitted materials
Working in small teams, students will be asked to critique a medicinal chemistry example from the literature and proposed improved molecules. The critique and design proposals will be commicated in the form of a short team presentation followed by discussion.
Minimum requirements and assessment criteria
Scale 1-5; participation in the final team presentation/exam is mandatory
Examination topics
1. The thermodynamics of drug-target binding
2. The importance of water
3. Molecular interactions
4. Drug design strategies & medicinal chemistry rules of thumb
2. The importance of water
3. Molecular interactions
4. Drug design strategies & medicinal chemistry rules of thumb
Reading list
Hunter, Christopher A. "Quantifying intermolecular interactions: guidelines for the molecular recognition toolbox." Angewandte Chemie International Edition 43.40 (2004): 5310-5324.
Bissantz, Caterina, Bernd Kuhn, and Martin Stahl. "A medicinal chemist’s guide to molecular interactions." Journal of medicinal chemistry 53.14 (2010): 5061-5084
McConnell, Darryl B. "Biotin’s lessons in drug design." Journal of Medicinal Chemistry 64.22 (2021): 16319-16327.
Bissantz, Caterina, Bernd Kuhn, and Martin Stahl. "A medicinal chemist’s guide to molecular interactions." Journal of medicinal chemistry 53.14 (2010): 5061-5084
McConnell, Darryl B. "Biotin’s lessons in drug design." Journal of Medicinal Chemistry 64.22 (2021): 16319-16327.
Association in the course directory
CH-FE, BC-Wahl, Freie Wahlfächer und Transferable Skills
Last modified: Mo 22.07.2024 14:26
1. Classes of small molecule drugs an introduction
2. Classes of drug targets an introduction
3. The thermodynamics of drug-target binding
4. The importance of water
5. Molecular interactions – up close & personal
6. Drug design strategies & medicinal chemistry rules of thumb
7. An introduction to finding hits in the vastness of chemical space
Further topics in medicinal chemistry that will not be covered in the course are (1) optimization of cellular and in vivo efficacy, (2) selectivity and toxicity, (3) drug distribution, metabolism and pharmacokinetics