Universität Wien
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300123 VO Gene expression (2016S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Details


Information

Aims, contents and method of the course

Lecture Content:
1. Molecular mechanisms of transcriptional control in bacteria
- promoters and their recognition by RNA polymerase
- Mechanisms of transcriptional control of bacterial operons: activators, repressors, 2-component systems
2. Molecular mechanisms of transcriptional control in eukaryotes:
- Promotors of RNA Polymerases I, II and III
- methodology for the analysis of gene expression
- structure-function relationsships in transcription factors
- Transcriptional initiation general transkription factors and coactivators
- chromatin structure and its influence on transcriptional activity of RNA polymerase II
- signals and molecular mechanisms of transcription factor activation
3. RNA processing
- RNA splicing
- RNA stability in bacteria and eukaryots
4. Translation and translational control in in bacteria and eukaryots
- Regulation and function of initiation factors
- Translational elongation and reprogramming of the genetic code
- Translational termination and ribosome recycling

Assessment and permitted materials

Written exam

Examens will take place at the beginning of July, in October and in December 2016, and in January 2017.

Minimum requirements and assessment criteria

Insight and knowledge concerning fundamental principles and mechanisms of transciptional and posstranscriptional regulation of gene expression

Examination topics

Course

Reading list

Decker:
Latchman: Gene Control, second ed.
Armstrong: Epigentics
Lim/Mayer/Pawson: Cell signaling

Association in the course directory

BMB 2, BMG 4, B-BMB 2, B-BMG 4, BAN 6,BBO 8, BOE 11,BPB 11,BZO 11

Last modified: Mo 07.09.2020 15:43