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300123 VO Gene expression (2017S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie


Language: English

Examination dates



IMBA-HS/Dr.Bohrgasse 3, 1030 Wien.
Beginn: 7.3.2017, 9:30. Anschließend jeweils Di. 9.30 - 11.30 Uhr
ACHTUNG, am 4.4. im SR 1/BZB, Dr.Bohrgasse 9,1030 Wien.


Aims, contents and method of the course

Lecture Content:

1. Molecular mechanisms of transcriptional control in bacteria
- promoters and their recognition by RNA polymerase
- Mechanisms of transcriptional control of bacterial operons: activators, repressors, 2-component systems

2. Molecular mechanisms of transcriptional control in eukaryotes:
- Promotors of RNA Polymerases I, II and III
- methodology for the analysis of gene expression
- structure-function relationsships in transcription factors
- Transcriptional initiation general transkription factors and coactivators
- chromatin structure and its influence on transcriptional activity of RNA polymerase II
- signals and molecular mechanisms of transcription factor activation

3. RNA processing
- RNA splicing
- RNA stability in bacteria and eukaryots

4. Translation and translational control in in bacteria and eukaryots
- Regulation and function of initiation factors
- Translational elongation and reprogramming of the genetic code
- Translational termination and ribosome recycling

Assessment and permitted materials

Written exam

Examens will take place at the beginning of July, in October and in December 2017, and in January or February 2018.

Minimum requirements and assessment criteria

Insight and knowledge concerning fundamental principles and mechanisms of transciptional and posstranscriptional regulation of gene expression

Examination topics


Reading list

Wird in der ersten Vorlesungsstunde des jeweiligen Vortragenden bekanntgegeben
Latchman: Gene Control, second ed.
Armstrong: Epigentics
Lim/Mayer/Pawson: Cell signaling

Association in the course directory

BMB 2, BMG 4, B-BMB 2, B-BMG 4, BAN 6,BBO 8, BOE 11,BPB 11,BZO 11

Last modified: Mo 07.09.2020 15:43