Universität Wien FIND

300308 VO Human Evolutionary Genetics: genomic, genes, diseases (2017S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie


Language: English

Examination dates


Classes (iCal) - next class is marked with N

07.03.2017; 16.00 - 17:30; HS1 Biozentrum Althanstrasse

Tuesday 07.03. 16:00 - 17:30 Hörsaal 1
Tuesday 14.03. 16:00 - 17:30 Hörsaal 1
Tuesday 21.03. 16:00 - 17:30 Hörsaal 1
Tuesday 28.03. 16:00 - 17:30 Hörsaal 1
Tuesday 04.04. 16:00 - 17:30 Hörsaal 1
Tuesday 25.04. 16:00 - 17:30 Hörsaal 1
Tuesday 02.05. 16:00 - 17:30 Hörsaal 1
Tuesday 09.05. 16:00 - 17:30 Hörsaal 1
Tuesday 16.05. 16:00 - 17:30 Hörsaal 1
Tuesday 23.05. 16:00 - 17:30 Hörsaal 1
Tuesday 30.05. 16:00 - 17:30 Hörsaal 1
Tuesday 13.06. 16:00 - 17:30 Hörsaal 1
Tuesday 20.06. 16:00 - 17:30 Hörsaal 1


Aims, contents and method of the course

The aim of this lecture is to provide students with knowledge and understanding of the scientific fields of human genetics, genomics and evolutionary genetics. This lecture will prepare students to understand how genetics, genomics and evolutionary genetics can be utilised to elucidate human phenotypic traits such as human diseases, host defence and behaviours.

The first part of this lecture introduces students to the structure of the human genome, the key aspects of human chromosome biology, human autosomal/X and Y-linked inheritance, gene functions and regulation and epigenetics. In the second part students will be briefly introduced to the state-of-the-art methods used in genomics and genetics. The third part of this lecture aims to provide an understanding of the concepts of human evolutionary genetics, population genetics, and anthropological genetics. Students will gain insights how various evolutionary processes (e.g., natural selection, genetic drift, mutation, and migration) influence human genomic diversity. In the fourth part students will gain knowledge that is required to understand how genomic variation can contribute to phenotypic variation. In this part, there will be an emphasis on immunogenetics and human diseases, and on neurogenetics and human behaviours (research-focused lectures providing case-studies); focusing on how genomic variation can directly or indirectly affect the risk to develop diseases, contribute to host defence, and influences human behaviours.

Teaching and learning methods: Lectures, handouts, and presentations (PowerPoint slides will be provided on Moodle).

Assessment and permitted materials

Written exam. Scientific (pocket) calculator.

Minimum requirements and assessment criteria

Student should gain knowledge and understanding:
i) the basis of human genomic structure and variation;
ii) the basis of human chromosome biology and heredity;
iii) gene function, regulation, and transcription;
iv) the role of epigenetic modification in genomic regulation;
v) methods used to study human genomes and genes;
vi) the theoretical and analytical methods used in evolutionary genetics, population genetics and anthropological genetics;
vii) how genomic variation can contribute to the variation of human phenotypic traits (diseases, host defense, behaviors);
viii) applying the gained knowledge to research questions/problems.

Examination topics

Lectures, handouts, and presentations.

Reading list

Human Evolutionary Genetics
Mark A. Jobling, Edward Hollox , Mathew Hurles, Toomas Kivisild, Chris Tyler-Smith.
Publication Date: June 25, 2013 | ISBN-10: 0815341482 | ISBN-13: 978-0815341482 | Edition: 2.

Human Molecular Genetics (4th ed.)
Tom Strachan & Andrew Read
Publication Date: April 2, 2010 | ISBN-10: 0815341490 | ISBN-13: 978-0815341499 | Edition: 4.

The Princeton Guide to Evolution
Jonathan B. Losos (editor in chief), David A. Baum, Douglas J. Futuyma, Hopi E. Hoekstra, Richard E. Lenski, Allen J. Moore, Catherine L. Peichel, Dolph Schluter & Michael C. Whitlock (editors). Publication Date: 2013, ISBN: 9780691149776. eBook ISBN: 9781400848065.

Online Genetics Education Resources: https://www.genome.gov/10000464/online-genetics-education-resources/

Human Genome Resources: https://www.ncbi.nlm.nih.gov/genome/guide/human/

Online Mendelian Inheritance in Man: https://www.omim.org/

Journal Articles:
Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713). Human evolution: a tale from ancient genomes.

Nature. 2010 (467):1061-73 | doi:10.1038/nature09534. A map of human genome variation from population-scale sequencing.

Nature. 2016 Jun 9;534(7606):200-5. doi: 10.1038/nature17993. The genetic history of Ice Age Europe.

Nature. 2014 Mar 20;507(7492):354-7. doi: 10.1038/nature12961. Epub 2014 Jan 29.
The genomic landscape of Neanderthal ancestry in present-day humans.

Association in the course directory

B-BAN 4, UF BU 10, BAN 2

Last modified: Sa 22.10.2022 00:30