300308 VO Human Evolutionary Genetics: genomic, genes, diseases (2018S)
Labels
Details
Language: English
Examination dates
Tuesday
26.06.2018
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
25.09.2018
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Wednesday
12.12.2018
13:30 - 15:00
Seminarraum
Tuesday
29.01.2019
14:30 - 16:00
Seminarraum
Lecturers
Classes (iCal) - next class is marked with N
Tuesday
06.03.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
13.03.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
20.03.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
10.04.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
17.04.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
24.04.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
08.05.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
15.05.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
29.05.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
05.06.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
12.06.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Tuesday
19.06.
16:00 - 17:30
Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Information
Aims, contents and method of the course
Assessment and permitted materials
Written exam. Scientific (pocket) calculator.
Minimum requirements and assessment criteria
Student should gain knowledge and understanding:
i) human genomic structure and variation;
ii) human chromosome biology and heredity;
iii) gene function, regulation, and transcription;
iv) the role of epigenetic modification in genomic regulation;
v) methods used to study human genomes and genes;
vi) the theoretical and analytical methods used in evolutionary genetics, population genetics and anthropological genetics;
vii) how genomic variation can contribute to the variation of human phenotypic traits (diseases, host defense, behaviors);
viii) applying the gained knowledge to research questions/problems.
i) human genomic structure and variation;
ii) human chromosome biology and heredity;
iii) gene function, regulation, and transcription;
iv) the role of epigenetic modification in genomic regulation;
v) methods used to study human genomes and genes;
vi) the theoretical and analytical methods used in evolutionary genetics, population genetics and anthropological genetics;
vii) how genomic variation can contribute to the variation of human phenotypic traits (diseases, host defense, behaviors);
viii) applying the gained knowledge to research questions/problems.
Examination topics
Lectures, handouts, and presentations.
Reading list
Journal Articles:
Investigative Genetics 20156:6. Genome-wide insights into the genetic history of human populations. https://investigativegenetics.biomedcentral.com/articles/10.1186/s13323-015-0024-0Nature. 2010 (467):1061-73 | doi:10.1038/nature09534. A map of human genome variation from population-scale sequencing.Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713). pii: 20150484.Human evolution: a tale from ancient genomes. Llamas, Willerslev, Orlando.Curr Opin Genet Dev. 2015 Dec; 35: 9–15. The Evolution of the Human Genome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695266/
Investigative Genetics 20156:6. Genome-wide insights into the genetic history of human populations. https://investigativegenetics.biomedcentral.com/articles/10.1186/s13323-015-0024-0Nature. 2010 (467):1061-73 | doi:10.1038/nature09534. A map of human genome variation from population-scale sequencing.Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713). pii: 20150484.Human evolution: a tale from ancient genomes. Llamas, Willerslev, Orlando.Curr Opin Genet Dev. 2015 Dec; 35: 9–15. The Evolution of the Human Genome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695266/
Association in the course directory
B-BAN 4, UF BU 10, BAN 2
Last modified: Th 23.02.2023 00:25
The first part of this lecture introduces students to the structure of the human genome, the key aspects of human chromosome biology, human autosomal, mtDNA and X/Y-linked inheritance, gene functions and gene regulation and epigenetics. In the second part students will be briefly introduced to the state-of-the-art methods used in genomics and genetics. The third part of this lecture aims to provide an understanding of the concepts of human evolutionary genetics, population genetics, and anthropological genetics. Students will gain insights how various evolutionary processes (e.g., natural selection, sexual selection, genetic drift, mutation, recombination, and migration) influence human genomic diversity. In the fourth part students will gain knowledge that is required to understand how genomic variation can contribute to phenotypic variation. In this part, there will be an emphasis on immunogenetics and human diseases and on neurogenetics and human behaviours (research-focused lectures providing case-studies). Student will gain understanding how genomic variation can directly or indirectly affect the risk to develop diseases, contribute to host defence, and influences human behaviours.Teaching and learning methods: Lectures, handouts, and presentations (PowerPoint slides will be provided on Moodle).