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300308 VO Human Evolutionary Genetics: genomic, genes, diseases (2020S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first serve).

Details

Language: English

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

Monday 09.03. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 16.03. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 23.03. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 30.03. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 20.04. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 27.04. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 04.05. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 11.05. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 18.05. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG
Monday 25.05. 15:00 - 16:30 Hörsaal 1, UZA 1, Biozentrum Althanstraße 14, 1.008A EG

Information

Aims, contents and method of the course

The aim of this lecture is to provide students with knowledge and a good understanding of the scientific field of human genetics. The lectures prepare students in particular to understand how different evolutionary forces influence the human genome. Students learn about the key concepts of human evolutionary genetics and gain insights into how genetics can be used to elucidate the phenotypic traits such as diseases, the body's defenses and behavior.

The first part of the lectures introduce students to the structure of the human genome, the key aspects of chromosome biology, and autosomal, mtDNA and X/Y-linked inheritance; the basis of gene functions and the role of epigenetics in gene regulation. In the second part, students will be briefly introduced to the state-of-the-art methods used in human genetic studies. The third part of the lectures aims to provide an understanding of the key concepts of human evolutionary genetics, population genetics, and molecular anthropology. Students gain insight into how different evolutionary processes affect genetic diversity and learn how these concepts are used to understand genetic diversity at both an individual and population level. In the fourth part, students will gain understanding how human genomic variation can directly or indirectly affect the risk to develop diseases, contribute to host defence, and influences human behaviours. (Research-focused lectures providing case-studies).

Teaching and learning methods: Lectures, handouts, and presentations (PowerPoint slides will be provided on Moodle).

Assessment and permitted materials

Digital exam on Moodle in Open-Book-Format.

Minimum requirements and assessment criteria

Student should gain knowledge and understanding:
i) the structure of the human genome, the basics of chromosome biology and heredity;
ii) the basics of gene function, regulation, and transcription;
iii) the role of epigenetic modification in gene regulation;
iv) molecular methods used in human genetics/genomics;
v) the key concepts of human evolutionary genetics and population genetics;
vi) human genomic variation and function in human health, disease and behaviour
vii) applying the gained knowledge to research questions/problems.
For a positive grade, at least 50% of the exam questions must be answered correctly.

Examination topics

Lectures, handouts, and presentations. Textbooks: Human Evolutionary Genetics (2013, 2nd edition), Mark A. Jobling, Edward Hollox , Mathew Hurles, Toomas Kivisild, Chris Tyler-Smith
An Introduction to Molecular Anthropology (2016), Mark Stoneking
Human Molecular Genetics (5th ed.)
Tom Strachan & Andrew Read
Publication Date: December, 2018 | · ISBN-13: 9780815345893 | Edition: 5

Reading list

Human Evolutionary Genetics
Mark A. Jobling, Edward Hollox , Mathew Hurles, Toomas Kivisild, Chris Tyler-Smith.
Publication Date: June 25, 2013 | ISBN-10: 0815341482 | ISBN-13: 978-0815341482 | Edition: 2

An Introduction to Molecular Anthropology
Mark Stoneking
ISBN: 978-1-118-06162-6 December 2016 Wiley-Blackwell

Human Molecular Genetics (5th ed.)
Tom Strachan & Andrew Read
Publication Date: December, 2018 | · ISBN-13: 9780815345893 | Edition: 5

The Princeton Guide to Evolution
Jonathan B. Losos (editor in chief), David A. Baum, Douglas J. Futuyma, Hopi E. Hoekstra, Richard E. Lenski, Allen J. Moore, Catherine L. Peichel, Dolph Schluter & Michael C. Whitlock (editors). Publication Date: 2013, ISBN: 9780691149776. eBook ISBN: 9781400848065

Online Genetics Education Resources: https://www.genome.gov/10000464/online-genetics-education-resources/

Human Genome Resources: https://www.ncbi.nlm.nih.gov/genome/guide/human/

Online Mendelian Inheritance in Man: https://www.omim.org/

Introduction to Population Genetics - Lynn Jorde (2016): https://www.youtube.com/watch?v=PzG99bexziA

CARTA: DNA–Neandertal and Denisovan Genomes;Neandertal Genes in Humans;Neandertal Interbreeding: https://www.youtube.com/watch?v=FCzcPSMz1tA

Association in the course directory

UF BU 10, BAN 2

Last modified: Tu 05.01.2021 08:09