Universität Wien

300417 VO Methods in Cell Biology (2011S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Vorbesprechung 7. März, 2011, 14:00 Uhr
BZB/SR 3.Stock/ Dr. Bohr-Gasse 9, 1030 Wien.
Block: 2.5. bis 7.6.2011 jew. Montag und Mittwoch 13.00- 15.00 Uhr!!!
Time of lectures changed to 1:00 to 3:00 pm (instead of 2-4:00 pm)

May 2:Cell culture, protein expression and purification :Primary cultures, organtypical cultures, differentiation models, eukaryotic expression systems, vector systems - Andreas Brachner

May 4: Protein-Protein, Protein DNA interactions: In vitro binding assays, affinity (Scatchard), In situ analyses (IP), in vivo analyses, FRET, yeast two hybrid Bandshift, Footprinting, Chromatin-IP, Yeast one-hybrid Reporter Gene Assays - Andreas Brachner

May 9: Gene Silencing techniques RNA-Interferenz; Antisense, morpholino, epigenetics - Josef Gotzmann

May 11: Light Microscopy: Immunofluorescence, wide field, confocal, live cell imaging, FRAP, FRET - Josef Gotzmann

May 16: Dynamics and Spatial Organisation of the Genome, Chromosome Conformation Capture techniques, GFP-tagging of chromosomes, High-resolution mapping of gene territories - Alwin Köhler

May 18: Ananlyses of cell cycle and Tumorbiology Cell Cycle Stages (FACS, Elutriation, BrdU incorporation, proliferation marker, synchronization
EMT, telomeres / DNA damage, transgenic and knock out tumor models - Andreas Brachner, Roland Foisner

May 23: Proteomics: Protein-identification (LC-MS/MS, mass spec, bio-informatics - Christopher Gerner

May 25: Techniques in Lipid Biochemistry - Sascha Martens

May 30: X-crystallography Protein purification, Crystallisation, X-ray analyses, structure determination - Gang Dong

Details


Information

Aims, contents and method of the course

The lecture deals with modern state of the art methods and applications in molecular cell biological research. It is designed for students familiar with the basic theory and basic practical approaches in cell and molecular biology. The taught subjects are adapted annually to allow incorporation of new developments in the field. Currenly the topics include: modern light and electron microscopical techniques, life cell imaging, organotypical cell culture, epigenetic analyses, RNAi approaches, analyses of gene expression, cell cycle regulation, protein-protein and protein DNA interactions, DNA microarray techniques and proteomic approaches.

Assessment and permitted materials

Minimum requirements and assessment criteria

Examination topics

Reading list


Association in the course directory

MMB III-2, MMB IV-2, MMB W-2, M202, M210

Last modified: Mo 07.09.2020 15:43