300693 VO Macromolecular Crystallography (2016S)

The following topics will be covered:

* sources of X-rays

* crystallisation techniques

* symmetry (point groups, space groups), unit cell, Bravais lattice

* scattering of X-rays, atomic form factor, structure factor

* waves, diffraction of molecules and crystals, Fourier transform; electron density

* set-up of MX diffraction experiment and detectors

* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion

* density modification techniques

* structure refinement and analysis