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301101 VO Epigenetics- From basic mechanisms to medical applications (2019W)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Registration/Deregistration

Details

Language: English

Examination dates

Lecturers

Classes

Block, täglich 04 .11. bis 26. 11.2019 von 17:00 bis 18:30 Uhr
Grosser Hörsaal/Histologie am Zentrum für Anatomie und Zellbiologie Schwarzspanierstraße 17, 1090 Wien


Information

Aims, contents and method of the course

To provide an introduction into basic epigenetic mechanisms and illustrate the role of chromatin for regulating different physiological and developmental processes as well as its involvement in disease.
Part Seiser:
1. Introduction
History of Epigenetics
Chromatin composition
2. Basic epigenetic mechanisms
DNA methylation
Histone modification/remodeling
Non-coding RNA
3. Epigenetic Phenomena
Imprinting
X-chromosome inactivation
Position effect variegation/Drosophila Epigenetics
(Wolfgang Miller)
4. Techniques to study the epigenome

Part Egger:
1. Epigenetic signatures in development and differentiation
Reprogramming of the epigenome during germ cell formation and after fertilization
The concept of cellular memory (Polycomb- Trithorax)
2. Artificial epigenetic reprogramming
Cloning, induced pluripotent stem cells
3. Influence of the Environment / Epigenetic alterations in disease
Tumor epigenetics
Imprinting defects
Complex disease
Mouse models to study epigenetics
4. Epigenetic therapy
5. Development of epigenetic biomarkers

Assessment and permitted materials

Written exam.

Minimum requirements and assessment criteria

A minimum of 55% of the achievable points is necessary for a positive grade.
sehr gut 90-100%
gut 80-89%
befriedigend 70-79%
genügend 55-69%
nicht genügend 0-54%

Examination topics

Contents of the course units, PDF of power point presentations on Moodle.

Reading list

Provided on Moodle.

Association in the course directory

MGE III-1, MMB IV-2, MMB IV-3, MMB W-2, PhD-MB 3, MMEI III, UF MA BU 01, UF MA BU 04,

Last modified: We 19.08.2020 07:49