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301123 VO Gene expression (2018S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Details

Language: English

Examination dates

Lecturers

Classes

Ort: IMBA-HS, Dr.Bohrgasse 3, 1030 Wien.
Beginn 6.3.2018
jeweils Di. 9.30 - 11.30 Uhr
Zusätzliche Termine: 17.5. 12.00 - 14.00,18.5. 14.00-16.00 Uhr sowie 30.5. 12.00 - 14.00 Uhr
ACHTUNG, am 19.6.2018 im SR 1/6.Stock, Dr.Bohrgasse 9,1030 Wien.


Information

Aims, contents and method of the course

Lecture Content:
1. Molecular mechanisms of transcriptional control in bacteria - promoters and their recognition by RNA polymerase - Mechanisms of transcriptional control of bacterial operons: activators, repressors, 2-component systems
2. Molecular mechanisms of transcriptional control in eukaryotes: - Promotors of RNA Polymerases I, II and III - methodology for the analysis of gene expression - structure-function relationships in transcription factors - Transcriptional initiation general transcription factors and coactivators - chromatin structure and its influence on transcriptional activity of RNA polymerase II - signals and molecular mechanisms of transcription factor activation
3. RNA processing - RNA splicing - RNA stability in bacteria and eukaryots
4. Translation and translational control in in bacteria and eukaryots - Regulation and function of initiation factors - Translational elongation and reprogramming of the genetic code - Translational termination and ribosome recycling

Assessment and permitted materials

Written exam

Minimum requirements and assessment criteria

Insight and knowledge concerning fundamental principles and mechanisms of transciptional and posstranscriptional regulation of gene expression
points:
10,6 - 12 : very good (1)
9,1-10,5 : good (2)
7,6-9: satisfactory (3)
6-7,5: sufficient (4)
<6: insufficient (5)

Examination topics

Content of the course

Reading list

Slides of the lecture will be provided in Moodle, additional literature or books will be mentioned during the lecture and on the slides

Association in the course directory

BMB 2, BMG 4, B-BMB 2, B-BMG 4, BAN 6,BBO 8, BOE 11,BPB 11,BZO 11

Last modified: Mo 07.09.2020 15:44