301185 VO Structural Bioinformatics I (2021W)
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Details
Language: English
Examination dates
Lecturers
Classes
see german version
Information
Aims, contents and method of the course
Programme Introduction to the molecular graphics and analysis of the most common protein folds with RasMol, Pymol and Chimera. Measurements of structural similarity between proteins, theory and applications (Dalilite, CE, PDBeFold and other tools). Databases of macromolecular structures: the Protein Data Bank, the wwPDB and the ePDB. Databases of structural domains: CATH, SCOP, and SCOP2. Databases of protein domains: Pfam, InterPro, InterProScan. Databases of computational models: ModBase and BioModels. Validation of experimental macromolecular structures. The problem of data redundancy.
Assessment and permitted materials
Oral exam
Minimum requirements and assessment criteria
The student must be able to compare two protein three-dimensional structures, be aware of the most important biological databases, and be able to solve basic exercises of molecular graphics.
Examination topics
Here is a list of specific topics: Superposition, rmsd, m-score, TM-score, techniques of superposition, basic database theory, PDB, CATH, SCOP, ModBase, DisProt, MobiDB, representativeness and redundancy, PISCES, PDBselect.
Reading list
Association in the course directory
MMB II-2, MMB W-2, MGE III-2, MMEI III, M-WZB, PhD MB 1,UF MA BU 01, UF MA BU 04
Last modified: We 01.06.2022 14:09