301450 VO Macromolecular Crystallography (2018S)
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Details
Language: English
Lecturers
Classes
The lectures will be on Tuesday 16 - 19h in the seminar room of
Dept. Structural and Computational Biology, Campus Vienna Biocenter /5, 1030 Wien.
Information
Aims, contents and method of the course
The following topics will be covered the major topic of macromolecular crystallography and will provide students with a comprehensive overview of all the steps required to generate a three-dimensional structural information on biological macromolecules:* sources of X-rays* crystallisation techniques* symmetry (point groups, space groups), unit cell, Bravais lattice* scattering of X-rays, atomic form factor, structure factor* waves, diffraction of molecules and crystals, Fourier transform; electron density* set-up of MX diffraction experiment and detectors* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion* density modification techniques* structure refinement, structure validation and analysis
Assessment and permitted materials
Oral or written exam, depending on the number of students.
Minimum requirements and assessment criteria
Examination topics
Reading list
Association in the course directory
MMB II-2, MMB W-2, MMEI III, CHE II-6
Last modified: Mo 07.09.2020 15:44