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301450 VO Macromolecular Crystallography (2018S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie


Language: English



The lectures will be on Tuesday 16 - 19h in the seminar room of
Dept. Structural and Computational Biology, Campus Vienna Biocenter /5, 1030 Wien.

The first lecture will be in 13.3. 2018.


Aims, contents and method of the course

The following topics will be covered the major topic of macromolecular crystallography and will provide students with a comprehensive overview of all the steps required to generate a three-dimensional structural information on biological macromolecules:

* sources of X-rays

* crystallisation techniques

* symmetry (point groups, space groups), unit cell, Bravais lattice

* scattering of X-rays, atomic form factor, structure factor

* waves, diffraction of molecules and crystals, Fourier transform; electron density

* set-up of MX diffraction experiment and detectors

* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion

* density modification techniques

* structure refinement, structure validation and analysis

Assessment and permitted materials

Oral or written exam, depending on the number of students.

Minimum requirements and assessment criteria

Examination topics

Reading list

Association in the course directory


Last modified: Mo 07.09.2020 15:44