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301450 VO Macromolecular Crystallography (2019S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first serve).

Details

Language: English

Examination dates

Lecturers

Classes

Lectures of Macromolecular crystallography will be according to this schedule:

Date Day Time

09.04.19 TUE 16-19
10.04.19 WED 15-18
11.04.19 THU 16-19
12.04.19 FR 16-19
EASTER HOLIDAYS

29.04.19 MO 15-18
30.04.19 TUE 16-19

02.05.19 THU 16-19
03.05.19 FR 16-19

07.05.19 TUE 16-19
08.05.19 WED 15-18
09.05.19 THU 16-19
10.05.19 FR 16-19

14.05.19 TUE 16-19
15.05.19 WED 15-18
16.05.19 THU 16-19
17.05.19 FR 16-19
In the Seminar room of Dept. Structural and Computational Biology, Campus Vienna Biocenter /5, 1030 Wien.


Information

Aims, contents and method of the course

The following topics will be covered the major topic of macromolecular crystallography and will provide students with a comprehensive overview of all the steps required to generate a three-dimensional structural information on biological macromolecules:

* sources of X-rays

* crystallisation techniques

* symmetry (point groups, space groups), unit cell, Bravais lattice

* scattering of X-rays, atomic form factor, structure factor

* waves, diffraction of molecules and crystals, Fourier transform; electron density

* set-up of MX diffraction experiment and detectors

* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion

* density modification techniques

* structure refinement, structure validation and analysis

Assessment and permitted materials

Oral or written exam, depending on the number of students.

Minimum requirements and assessment criteria

Examination topics

Reading list


Association in the course directory

MMB II-2, MMB W-2, MMEI III, CHE II-6

Last modified: We 19.08.2020 08:08