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301450 VO Macromolecular Crystallography (2022S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie
MIXED

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

Language: English

Lecturers

Classes

see german version


Information

Aims, contents and method of the course

The following topics will be covered the major topic of macromolecular crystallography and will provide students with a comprehensive overview of all the steps required to generate a three-dimensional structural information on biological macromolecules:
* sources of X-rays
* crystallisation techniques
* symmetry (point groups, space groups), unit cell, Bravais lattice
* scattering of X-rays, atomic form factor, structure factor
* waves, diffraction of molecules and crystals, Fourier transform; electron density
* set-up of MX diffraction experiment and detectors
* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion
* density modification techniques
* structure refinement, structure validation and analysis

Assessment and permitted materials

Oral or written exam, depending on the number of students.
Oral exam in Zoom or written digital exam.

Minimum requirements and assessment criteria

Attendance and active participation during the lecture course, >60% correct answers of exam for passing grade.
Assessment criteria:
100-90%: excellent (1)
89-80%: good (2)
79-70%: satisfactory (3)
69-60%: sufficient (4)
< 59%: insufficient (5)

Examination topics

Contents of the lectures as given in the course lecture notes and handouts available on the Moodle.

Reading list

Will be provided by the lecturer in the first lecture.

Association in the course directory

MMB II-2, MMB W-2, MMEI III, CHE II-6

Last modified: Su 06.03.2022 11:49