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301463 VO Biophysical chemistry of macromolecules (2021S)


2.00 ECTS (1.00 SWS), SPL 30 - Biologie


Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).


Language: English

Examination dates



Lectures will be on Wednesdays at 13:15h in ZOOM, according to the schedule below:

5.5. Thermodynamics (Robert Konrat)
12.5. Dynamic and kinetic aspects (Georg Kontaxis)
19.5. Folding and polymer theory (Bojan Zagrovic)
26.5. Biophysical Chemistry of Proteins (Thomas Leonard)
2.6. Biophysical Chemistry Nucleic Acids (Sebastian Falk)
9. 6. Biophysical Chemistry of lipids (Anton Polyansky)
16.6. Mechanisms of macromolecular interactions/Affinity and specificity (Kristina Djinovic Carugo)

Meeting-ID: 943 2547 8611
Passcode 908606


Aims, contents and method of the course

This lecture course is aimed at students at the master level and covers the physico-chemical description of biological macromolecules, which is relevant for their function. In the course of this structure and dynamic behavior of biopolymers are covered. The central topics that will be discussed include: governing principles of conformational organization of biomolecules, biomolecular function and dynamic behavior. They are explained in terms of molecular driving forces, and related to basic (bio-)physical principles of thermodynamics and kinetics and polymer theory through a mathematical description. The aim of this course is to give students a fundamental understanding of the basics of molecular biophysics in terms of first principles. Emphasis is put on a consistent quantitative description of the biophysical phenomena. The course is held by different lecturers which will cover the subjects of their expertise.
The central topics that will be discussed include: advanced principles of conformational organization of biomolecules, biomolecular kinetics and thermodynamics, molecular driving forces, polymer theory and principles of macromolecular interactions.

Assessment and permitted materials

Oral or written exam, depending on the number of students.
Oral exam in Zoom or written exam.

Minimum requirements and assessment criteria

Attendance and active participation during the lecture course, >60% correct answers of exam for passing grade.
Assessment criteria:
100-90%: excellent (1)
89-80%: good (2)
79-70%: satisfactory (3)
69-60%: sufficient (4)
< 59%: insufficient (5)

Examination topics

Contents of the lectures as given in the course lecture notes and handouts available on the Moodle.

Reading list

The MAJOR SOURCE for this lecture series is the book:
John Kuriyan, Boyana Konforti, David Wemmer - The Molecules of Life: Physical and Chemical Principles

Additional reading:
K Dill -Molecular Driving Forces; Cantor & Schimmel -Biophysical Chemistry

Association in the course directory


Last modified: Tu 28.09.2021 16:09