310107 VO Fundamentals in Systems Biology (2005W)

VO, 4 ECTS credits
Molecular systems biology investigates cells and organisms as complex chemical systems. The goals are an understanding of global relations at the molecular level and insight into the emergence of new properties. The course starts with introductions into chemical reaction kinetics, into the theory of networks and their dynamics as well as the analysis of relations between structures and functions. The main part of the course discusses various models of cellular dynamics and its applications to examples from molecular biology. Such examples are the glycolytic chain, the tricarboxylic acid cycle, and the mitochondrial redox chain. Finally, several examples of computer simulations of complete cells are presented and discussed.