320003 VO Biophysical Pharmaceutical Chemistry (2010W)
Labels
Details
Language: German
Examination dates
Thursday
20.01.2011
Tuesday
01.02.2011
Tuesday
22.02.2011
Thursday
03.03.2011
Monday
07.03.2011
Thursday
07.04.2011
Thursday
12.05.2011
Thursday
09.06.2011
Thursday
14.07.2011
Wednesday
28.09.2011
Friday
28.10.2011
Thursday
24.11.2011
Wednesday
14.12.2011
Lecturers
Classes (iCal) - next class is marked with N
Tuesday
19.10.
13:00 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
25.10.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
08.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
09.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
15.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
16.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
16.11.
13:00 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
22.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
23.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
29.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
30.11.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
06.12.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
07.12.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
07.12.
13:00 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
13.12.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
14.12.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
10.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
11.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
17.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
18.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Thursday
20.01.
13:00 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Monday
24.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Tuesday
25.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Monday
31.01.
09:00 - 10:30
UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
Information
Aims, contents and method of the course
the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)
Assessment and permitted materials
Written exam, 10 questions, 100 points, 90 minutes
Minimum requirements and assessment criteria
The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.
Examination topics
Language: German (material partly in English); powerpoint presentation, software demonstrations
Reading list
Association in the course directory
A210
Last modified: Sa 02.04.2022 00:27