320003 VO Biophysical Pharmaceutical Chemistry (2011W)
Labels
Achtung: Nur Prüfungstermine!!!Bitte registrieren sie sich in der Lernplattform
Details
Language: German
Examination dates
Thursday
26.01.2012
Thursday
16.02.2012
Monday
27.02.2012
Wednesday
21.03.2012
Thursday
26.04.2012
Wednesday
16.05.2012
Thursday
14.06.2012
Wednesday
04.07.2012
Tuesday
07.08.2012
10:30 - 12:15
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Tuesday
18.09.2012
Monday
08.10.2012
Thursday
15.11.2012
Thursday
13.12.2012
Lecturers
Classes (iCal) - next class is marked with N
Wednesday
21.03.
10:30 - 12:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
26.04.
13:30 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Wednesday
16.05.
12:00 - 13:30
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Thursday
14.06.
13:30 - 15:00
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Information
Aims, contents and method of the course
the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)
Assessment and permitted materials
Written exam, 10 questions, 100 points, 90 minutes
Minimum requirements and assessment criteria
The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.
Examination topics
Language: German (material partly in English); powerpoint presentation, software demonstrations
Reading list
Association in the course directory
A210
Last modified: Sa 02.04.2022 00:27