320003 VO Biophysical Pharmaceutical Chemistry (2015W)
Labels
Start: 1.12.2015
Tue, Wed 16:45-1815, Hs6
In Jan 2016: Tue, Wed 16:45-20:00, Hs 6
Tue, Wed 16:45-1815, Hs6
In Jan 2016: Tue, Wed 16:45-20:00, Hs 6
Details
Language: German
Examination dates
- Friday 29.01.2016 13:15 - 14:45 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Tuesday 16.02.2016 11:30 - 13:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Monday 18.04.2016 16:45 - 18:15 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Tuesday 21.06.2016 16:45 - 18:15 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
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Tuesday
26.07.2016
11:30 - 13:00
UZA2 Hörsaal 7 (Raum 2Z210) 2.OG
UZA2 Hörsaal 8 (Raum 2Z206) 2.OG - Tuesday 13.09.2016 09:45 - 11:15 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Tuesday 18.10.2016 09:45 - 11:15 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Tuesday 22.11.2016 13:15 - 14:45 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
- Wednesday 21.12.2016 08:00 - 09:30 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
Lecturers
Classes (iCal) - next class is marked with N
- Tuesday 01.12. 16:45 - 18:15 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 02.12. 16:45 - 18:15 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 09.12. 16:45 - 18:15 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Tuesday 15.12. 16:45 - 18:15 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 16.12. 16:45 - 18:15 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Tuesday 12.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 13.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Tuesday 19.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 20.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Tuesday 26.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
- Wednesday 27.01. 16:45 - 20:00 UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
Information
Aims, contents and method of the course
the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)
Assessment and permitted materials
written exam; 4 questions multiple choice (5 points/question), 8 questions text and/or calculations (10 points/question); grades: 0-50 points nicht genügend (5; failed)), 51-63 points genügend (4), 64-76 points befriedigend (3), 77-89 points gut (2), 90-100 points sehr gut (1); duration: 90 minutes; allowed material: simple calculator
Minimum requirements and assessment criteria
The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.
Examination topics
Language: German (material partly in English); powerpoint presentation, software demonstrations
Reading list
Association in the course directory
A210
Last modified: Sa 02.04.2022 00:27