Universität Wien

320003 VO Biophysical Pharmaceutical Chemistry (2016W)

4.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Prüfungstermine:
06.03.2017 11.30 Uhr HS 8
28.04.2017 15.00 Uhr HS 8
30.05.2017 15.00 Uhr HS 8
23.06.2017 15.00 Uhr HS 8
Moodle u: stream

Details

Language: German

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

  • Wednesday 09.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Wednesday 16.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Thursday 17.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Wednesday 23.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Thursday 24.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Wednesday 30.11. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Thursday 01.12. 16:45 - 20:00 UZA2 Hörsaal 7 (Raum 2Z210) 2.OG
  • Wednesday 07.12. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG
  • Wednesday 14.12. 16:45 - 20:00 UZA2 Hörsaal 8 (Raum 2Z206) 2.OG

Information

Aims, contents and method of the course

the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)

Assessment and permitted materials

written exam; 4 questions multiple choice (5 points/question), 8 questions text and/or calculations (10 points/question); grades: 0-50 points nicht genügend (5; failed)), 51-63 points genügend (4), 64-76 points befriedigend (3), 77-89 points gut (2), 90-100 points sehr gut (1); duration: 90 minutes; allowed material: simple calculator

Minimum requirements and assessment criteria

The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.

Examination topics

Language: German (material partly in English); powerpoint presentation, software demonstrations

Reading list

Association in the course directory

A210

Last modified: Sa 02.04.2022 00:27