320020 VO Pharmacology of bone (2009W)
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Beginn :05.10.2009 um 13 Uhr(Vorbesprechung) auf 2D265
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Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
An introduction to mechanisms of bone resorption and formation, calcium and phosphate homeostasis and the mechanism of action of drugs to prevent bone degradation. This course will cover basic pharmacology concepts as well as specific drug classes related to metabolic bone diseases, such as osteoporosis. The first half of the course includes lectures on osteoclast and osteoblast function, receptors, regulation by local and systemic factors. The second half of the course includes lectures on methods to isolate and culture bone cells, therapeutic agents, pharmacokinetics and drug metabolism in bone diseases. Osteoporosis is the most common disease affecting the elderly and the most efficient therapy is prophylaxis. Thus, pharmacists have an important role in informing patients about the risks of bone loss and preventive therapy.
Examination topics
Reading list
Association in the course directory
A400
Last modified: Fr 31.08.2018 08:57
o Osteoblasts: Stem cells, The osteoblast family, Regulation of osteoblast proliferation and differentiation
o Osteocytes
o Osteoclasts: Development, morphology and physiological function" Physiology and Pathophysiology of bone metabolism and mineral homeostasis
o Systemic Regulators
" Parathyroid hormone (PTH) and PTH-related peptide
" Vitamin D-System, Calcitonin
" Estrogens and Progesterones
o Local Regulators
" Bone morphogenetic proteins, transforming growth factor
" Colony stimulating factors, tumor necrosis factor, interleukins
" Prostaglandins" Methods: Isolation, in vitro bone cell culture, determination of bone cell activity" Approaches to prevent osteoporosis and treat bone diseases
o Nutrition, physical Exercise, calcium and vitamin D
o Hormone replacement therapy
o Bisphosphonates
o Future therapies