Universität Wien

320029 VO General principles of drug action and pharmakokinetics (2013S)

3.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Beginn: 12.03.2013
Di, Mi 12.30-14.00 Uhr HS 7
ACHTUNG! am 10.04./17.04.und 23.04.2013 findet die VO im Hs 6 statt!!

Prüfungstermine:
25.04.2013 10.30 Uhr HS 8
20.06.2013 10.00 Uhr Hs 7
09.08.2013 wird noch bekannt gegeben!
20.09.2013 wird noch bekannt gegeben!

Details


Information

Aims, contents and method of the course

Drug-receptor-interactions, classification of different targets for drug action (receptors, ion channels, enzymes, carrier molecules), structure and functions of selected receptors (ligand-gated ion channels, G-protein-coupled receptors, nuclear receptors, kinase-linked receptors), pharmacology of second messenger systems (e.g. the adenylate cyclase/cyclic AMP system and the phospholipase C/inositol phosphate system), interaction of ion channels with G-proteins, the molecular architecture of voltage gated ion channels, their function and pharmacological properties, the release of chemical mediators, routes of drug administration, absorption, distribution, elimination (phase I reactions, the cytochrome P450 system), phase II reactions, first pass effect, active drug metabolites, renal excretion, pharmacokinetics (including compartment models), the autonomic nervous system (cholinergic and noradrenergic transmission, transmission by purines and 5-hydroxytryptamin), peptides and proteins as drugs, nitric oxide, local hormones.

Assessment and permitted materials

Minimum requirements and assessment criteria

To describe the general principles of drug action with focus on cellular and molecular mechanisms and signal transduction cascades. The course includes the mechanisms of drug absorption, distribution and elimination and pharmacokinetics.

Examination topics

Reading list


Association in the course directory

A225

Last modified: Sa 02.04.2022 00:27