Universität Wien

320084 PR Drug Synthesis - Laboratory Course (2008S)

9.00 ECTS (12.00 SWS), SPL 32 - Pharmazie
Continuous assessment of course work

Details


Information

Aims, contents and method of the course

ECTS: 9.0
Glassware of a preparativ organic laboratory; weighting; adding of compounds to a reaction vessel; control of temperature; extraction techniques; distillation (at atmospheric pressure - at diminished pressure); fractional distillation; recrystallation; drying of solids and liquids; determination of melting points; steam distillation; azeotropic distillation - water separation unit, adding of compounds via septum and syringe under a nitrogen atmosphere; recording of results; general instructions for safe working.
Program: Separation of a mixture of two liquid compound by fractionated distillation under atmospheric pressure and diminished pressure; purification of a contaminated solid compound; isolation of an org. acid or base, respectively, by extraction.
Eight syntheses: Reactions of carboxylic derivatives (esterification, acetylation); reactions of carbonyl compounds (acetals-, imines-, enamines- und oximes); condensation and addition ractions and rearrangement reaction (Aldol-, Knoevenagel-, Mannich-, Perkin-, Diels-Alder-reactions, benzilic acid rearrangement reaction); reductions (komplex hydrides) and oxidation reactions; syntheses of heterocyclic and aromatic compounds; Grignard-reactions (use of septum and syringe; nitrogen atmosphere); preparation of drugs.

Assessment and permitted materials

Minimum requirements and assessment criteria

The objective of the course is to teach the student in experimental techniques used in organic synthesis. This is illustrated by a number of important organic reactions. Practical training is given in this laboratory course.

Examination topics

Reading list


Association in the course directory

A202

Last modified: Fr 31.08.2018 08:57