320084 PR Drug Synthesis - Laboratory Course (2008S)
Continuous assessment of course work
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Details
Language: German
Lecturers
- Helmut Spreitzer
- Barbara Datterl
- Christiane Egyed
- Miriam Emich
- Norbert Haider
- Wolfgang Holzer
- Stephanie Parth
- Eva Schirmer
- Doris Alexandra Schütz
- Manochehr Shahabi Mohammad Shahi
Classes
Currently no class schedule is known.
Information
Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
The objective of the course is to teach the student in experimental techniques used in organic synthesis. This is illustrated by a number of important organic reactions. Practical training is given in this laboratory course.
Examination topics
Reading list
Association in the course directory
A202
Last modified: Fr 31.08.2018 08:57
Glassware of a preparativ organic laboratory; weighting; adding of compounds to a reaction vessel; control of temperature; extraction techniques; distillation (at atmospheric pressure - at diminished pressure); fractional distillation; recrystallation; drying of solids and liquids; determination of melting points; steam distillation; azeotropic distillation - water separation unit, adding of compounds via septum and syringe under a nitrogen atmosphere; recording of results; general instructions for safe working.
Program: Separation of a mixture of two liquid compound by fractionated distillation under atmospheric pressure and diminished pressure; purification of a contaminated solid compound; isolation of an org. acid or base, respectively, by extraction.
Eight syntheses: Reactions of carboxylic derivatives (esterification, acetylation); reactions of carbonyl compounds (acetals-, imines-, enamines- und oximes); condensation and addition ractions and rearrangement reaction (Aldol-, Knoevenagel-, Mannich-, Perkin-, Diels-Alder-reactions, benzilic acid rearrangement reaction); reductions (komplex hydrides) and oxidation reactions; syntheses of heterocyclic and aromatic compounds; Grignard-reactions (use of septum and syringe; nitrogen atmosphere); preparation of drugs.