320084 PR Drug Synthesis - Laboratory Course (2012W)

Glassware of a preparativ organic laboratory; weighting; adding of compounds to a reaction vessel; control of temperature; extraction techniques; distillation (at atmospheric pressure - at diminished pressure); fractional distillation; recrystallation; drying of solids and liquids; determination of melting points; steam distillation; azeotropic distillation - water separation unit, adding of compounds via septum and syringe under a nitrogen atmosphere; recording of results; general instructions for safe working.

Program: Separation of a mixture of two liquid compound by fractionated distillation under atmospheric pressure and diminished pressure; purification of a contaminated solid compound; isolation of an org. acid or base, respectively, by extraction.

Eight syntheses: Reactions of carboxylic derivatives (esterification, acetylation); reactions of carbonyl compounds (acetals-, imines-, enamines- und oximes); condensation and addition ractions and rearrangement reaction (Aldol-, Knoevenagel-, Mannich-, Perkin-, Diels-Alder-reactions, benzilic acid rearrangement reaction); reductions (komplex hydrides) and oxidation reactions; syntheses of heterocyclic and aromatic compounds; Grignard-reactions (use of septum and syringe; nitrogen atmosphere); preparation of drugs.