320152 PR Drug analysis and drug development (2009S)

ECTS: 6.0
Content:
A: Quantitative determination of active substances in drugs (single compounds, mixtures, impurities) with instrumental methods:
Methods: Spectrophotometry, conductometry, potentiometry, amperometry, polarography, polarimetry, ion selective measurement, water content according to Karl-Fischer, HPLC with refraction index, UV, and fluorescent detection, capillary electrophoresis, enzymatic methods.
Studies concerning the pharmaceutical quality of active ingedients: identity, content, purity, impurity profile; determination of a drug with three selected methods (teamwork), validation of the analytical methods, statistical evaluation, GLP analysis, and discussion of methods and results.

B. Analytical, in silico and special synthetic methods in drug design (lead structure finding and lead structure optimization):
Genome und proteome analysis; biophysical pharmaceutical chemistry (microcalorimetry, ORCD measurements), in vitro and in silico interaction studies, molecular modeling, analysis of structure activity relationships, special synthetic methods (libaries by parallel or combinatorial solid phase synthesis, peptide synthesis, and oligonucleotide synthesis), documentation (chemical part of a "drug master file" - general, synthesis, analysis).

Teaching aim:
Main objective: Knowledge how to guarantee the pharmaceutical quality of drugs and how to identify and optimize drugs. Experience in handling the instruments used in quantitative analysis and syntheses; knowledge on computer assisted drug design; development of the ability for method selection, practical running, evaluation and documentation of analytical results.