321113 PR Drug Synthesis - Laboratory Course - B7 (2017W)

Glassware of a preparativ organic laboratory; weighting; adding of compounds to a reaction vessel; control of temperature; extraction techniques; distillation (at atmospheric pressure - at diminished pressure); fractional distillation; recrystallation; drying of solids and liquids; azeotropic distillation - water separation unit, adding of compounds via septum and syringe.
Program:
Distillation at normal pressure; distillation under reduced pressure; recrystallization; isolation of an organic acid or base, respectively, by extraction.
Eight syntheses: Reactions of carboxylic acids; reactions of carbonyl compounds; Aldol condensation, benzilic acid rearrangement reaction); reductions (sodium borohydride) and oxidation reactions; syntheses of heterocyclic compounds; Grignard-reactions (use of septum and syringe); preparation of drugs (nifedipine, phenytoin, paracetamol, acetylsalicylic acid).