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321113 PR Drug Synthesis - Laboratory Course - B7 (2020W)

(3 Kurse)

8.00 ECTS (8.00 SWS), SPL 32 - Pharmazie
Continuous assessment of course work

für nähere Informationen und Anmeldung siehe LV 321013



Aims, contents and method of the course

Glassware of a preparativ organic laboratory; weighting; adding of compounds to a reaction vessel; control of temperature; extraction techniques; distillation (at atmospheric pressure - at diminished pressure); fractional distillation; recrystallation; drying of solids and liquids; azeotropic distillation - water separation unit, adding of compounds via septum and syringe.
Distillation at normal pressure; distillation under reduced pressure; recrystallization; isolation of an organic acid or base, respectively, by extraction.
Eight syntheses: Reactions of carboxylic acids; reactions of carbonyl compounds; Aldol condensation, benzilic acid rearrangement reaction); reductions (sodium borohydride) and oxidation reactions; syntheses of heterocyclic compounds; Grignard-reactions (use of septum and syringe); preparation of drugs (nifedipine, phenytoin, paracetamol, acetylsalicylic acid).

Assessment and permitted materials

Evaluation is based on laboratory work; compulsory attendance.

Minimum requirements and assessment criteria

The objective of the course is to teach the student in experimental techniques used in organic synthesis. This is illustrated by a number of important organic reactions. Practical training is given in this laboratory course.

Examination topics

Laboratory course

Reading list

Organikum; Wiley-VCH

Association in the course directory

A202, BA13

Last modified: Mo 16.08.2021 11:48