Universität Wien

322010 VO Metabolism and Drug Interactions - M9 (2020S)

4.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Vorlesungszeiten:
06.05.2020 - 10.06.2020 Mittwoch, Donnerstag von 13.15-14.45 Uhr HS 5

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Details

Language: German

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

Die Lehrveranstaltung wird derzeit über online Tools abgehalten, wie Blackboard Collaborate (via Moodle), Go-to-meeting oder Videosequenzen (in Moodle) und entsprechenden Downloads von Unterichtsmaterialien

  • Wednesday 06.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 07.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 13.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 14.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 20.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 27.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 28.05. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 03.06. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 04.06. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 10.06. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 17.06. 13:15 - 14:45 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG

Information

Aims, contents and method of the course

Knowledge about drug metabolism with relevance for dosing and interaction with other co-adminisered drugs
Introduction of phase I and phase II drug metabolism
Substrates, inhibitors, inducers, pharmacogenetics of cytochrome P450 isoenzymes,
glucuronosyltransferases, sulfotransferases, acetyltransferases, gluthathion-S-transferases, methyltransferases
In vitro/in vivo correlation of drug metabolism, enzyme kinetics (Km, Vmax, Ki)
Interplay between drug metabolizing enzymes and drug transporters (ABC transporter, SLC carrier)
Interactions: drug/drug, food/drug, drug/transporter, drug/endogenous compounds
problem-based learning

Assessment and permitted materials

Written Examination
Duration: 60 min

Minimum requirements and assessment criteria

Minimum requirements and assessment criteria:
1: 37-40 points
2: 33-36 points
3: 29-32 points
4: 24-28 points
5: < 24 points

Examination topics

Lecture

Reading list

M.D. Coleman: Human drug metabolism - an introduction (Wiley-Blackwell, 2010)
B. Testa, S. Krämer: The biochemistry of drug metabolism: principles, redox reactions, hydrolysis (Wiley-VCH, 2008)
B.Testa, S. Krämer: The biochemistry of drug metabolism: conjugations, consequensces of metabolism, influencing factors (Wiley-VCH, 2010)
C. Ioannides: Enzyme systems that metabolise drugs and other xenobiotic (Wiley, 2001)
W. Kalow, U.A. Meyer, R.F. Tyndale: Pharmacogenomics (marcel Dekker, 2001)
A.D. Rodrigues: Drug-drug interactions (Informa Healthcare, 2008)
K.S. Pang, A.D. Rodrigues, R.M. Peter: Enzyme- and transporter-based drug-drug interactions (Springer, 2010)
Y.W.F. Lam, S.M. Huang, S.D. Hall: Herbal supplements-drug interactions (Taylor &Francis, 2006)
X. Xie: Drug metabolism in diseases (Academic Press, 2017)

Association in the course directory

A400, MA10

Last modified: Sa 02.04.2022 00:27