Universität Wien

322010 VO Metabolism and Drug Interactions - M9 (2021S)

4.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Vorlesungszeiten:
05.05./07.05./12.05./19.05./26.05.2021 13.15-14.45 Uhr HS 5
02.06./04.06./09.06./16.06./22.06./30.06.2021 13.15-14.45 Uhr HS 5
11.06.+18.06.2021 13.15-14.45 Uhr HS 6

Moodle

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).
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Details

Language: German

Lecturers

Classes (iCal) - next class is marked with N

Due to the pandemic and preference of students, the lectures will be recorded and uploaded to Moodle, no lecture will be in person; the same applies to exams, these will be online on Moodle, not in person

  • Wednesday 05.05. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 07.05. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 12.05. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 19.05. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 26.05. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 02.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 04.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 09.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 11.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
  • Wednesday 16.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 18.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 6 (Raum 2Z227) 2.OG
  • Tuesday 22.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 30.06. 13:15 - 14:45 Hybride Lehre
    UZA2 Hörsaal 5 (Raum 2Z202) 2.OG

Information

Aims, contents and method of the course

Knowledge about drug metabolism with relevance for dosing and interaction with other co-adminisered drugs
Introduction of phase I and phase II drug metabolism
Substrates, inhibitors, inducers, pharmacogenetics of cytochrome P450 isoenzymes,
glucuronosyltransferases, sulfotransferases, acetyltransferases, gluthathion-S-transferases, methyltransferases
In vitro/in vivo correlation of drug metabolism, enzyme kinetics (Km, Vmax, Ki)
Interplay between drug metabolizing enzymes and drug transporters (ABC transporter, SLC carrier)
Interactions: drug/drug, food/drug, drug/transporter, drug/endogenous compounds
problem-based learning

Assessment and permitted materials

Written Examination (Mulitple Choice, online)
Duration: 60 min

Minimum requirements and assessment criteria

Minimum requirements to pass are 60% of total points, assessment criteria:
1: 19-20 points
2: 17-18 points
3: 15-16 points
4: 12-14 points
5: < 12 points

Examination topics

Lecture and additional literature as identified in the lecture

Reading list

M.D. Coleman: Human drug metabolism - an introduction (Wiley-Blackwell, 2010)
B. Testa, S. Krämer: The biochemistry of drug metabolism: principles, redox reactions, hydrolysis (Wiley-VCH, 2008)
B.Testa, S. Krämer: The biochemistry of drug metabolism: conjugations, consequensces of metabolism, influencing factors (Wiley-VCH, 2010)
C. Ioannides: Enzyme systems that metabolise drugs and other xenobiotic (Wiley, 2001)
W. Kalow, U.A. Meyer, R.F. Tyndale: Pharmacogenomics (marcel Dekker, 2001)
A.D. Rodrigues: Drug-drug interactions (Informa Healthcare, 2008)
K.S. Pang, A.D. Rodrigues, R.M. Peter: Enzyme- and transporter-based drug-drug interactions (Springer, 2010)
Y.W.F. Lam, S.M. Huang, S.D. Hall: Herbal supplements-drug interactions (Taylor &Francis, 2006)
X. Xie: Drug metabolism in diseases (Academic Press, 2017)

Association in the course directory

A400, MA10

Last modified: Fr 12.05.2023 00:24