Universität Wien

322010 VO Metabolism and Drug Interactions - M9 (2022S)

4.00 ECTS (2.00 SWS), SPL 32 - Pharmazie
REMOTE

Vorlesungszeiten:
04./06./11./13./18./20./25./27.05.2022 15:0016:30 Uhr HS 5
01./03./08./10./17.06.2022 15:00-16:30 Uhr HS 5
Achtung! Am 15.06.2022 findet die VO im HS 4 statt!!
Moodle

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Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).
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Details

Language: German

Lecturers

Classes (iCal) - next class is marked with N

  • Wednesday 04.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 06.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 11.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 13.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 18.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 20.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 25.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 27.05. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 01.06. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 03.06. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 08.06. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Friday 10.06. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Wednesday 15.06. 15:00 - 16:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Friday 17.06. 15:00 - 16:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG

Information

Aims, contents and method of the course

Knowledge about drug metabolism with relevance for dosing and interaction with other co-adminisered drugs
Introduction of phase I and phase II drug metabolism
Substrates, inhibitors, inducers, pharmacogenetics of cytochrome P450 isoenzymes,
glucuronosyltransferases, sulfotransferases, acetyltransferases, gluthathion-S-transferases, methyltransferases
In vitro/in vivo correlation of drug metabolism, enzyme kinetics (Km, Vmax, Ki)
Interplay between drug metabolizing enzymes and drug transporters (ABC transporter, SLC carrier)
Interactions: drug/drug, food/drug, drug/transporter, drug/endogenous compounds
problem-based learning

Assessment and permitted materials

Written Examination (Mulitple Choice, online)
Duration: 60 min

Minimum requirements and assessment criteria

Minimum requirements to pass are 60% of total points, assessment criteria:
1: 19-20 points
2: 17-18 points
3: 15-16 points
4: 12-14 points
5: < 12 points

Examination topics

Lecture and additional literature as identified in the lecture

Reading list

M.D. Coleman: Human drug metabolism - an introduction (Wiley-Blackwell, 2010)
B. Testa, S. Krämer: The biochemistry of drug metabolism: principles, redox reactions, hydrolysis (Wiley-VCH, 2008)
B.Testa, S. Krämer: The biochemistry of drug metabolism: conjugations, consequensces of metabolism, influencing factors (Wiley-VCH, 2010)
C. Ioannides: Enzyme systems that metabolise drugs and other xenobiotic (Wiley, 2001)
W. Kalow, U.A. Meyer, R.F. Tyndale: Pharmacogenomics (marcel Dekker, 2001)
A.D. Rodrigues: Drug-drug interactions (Informa Healthcare, 2008)
K.S. Pang, A.D. Rodrigues, R.M. Peter: Enzyme- and transporter-based drug-drug interactions (Springer, 2010)
Y.W.F. Lam, S.M. Huang, S.D. Hall: Herbal supplements-drug interactions (Taylor &Francis, 2006)
X. Xie: Drug metabolism in diseases (Academic Press, 2017)

Association in the course directory

A400, MA10

Last modified: Mo 02.05.2022 14:50