322575 VU Pharmaceutical Nanotechnology - Lipid-based Applications - M7/M14 (2023W)
Continuous assessment of course work
Labels
Registration/Deregistration
Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).
- Registration is open from Mo 04.12.2023 12:00 to We 10.01.2024 12:00
- Deregistration possible until We 10.01.2024 12:00
Details
Language: English
Lecturers
Classes
Monday January 22, 2024 - 9:45 a.m. - 11:15 a.m. 2E411
Tuesday January 23rd, 2024 - 9:45 a.m. - 11:15 a.m. 2E411
Wednesday January 24th, 2024 - 9:45 a.m. - 11:15 a.m. 2F161
Thursday January 25th, 2024 - 9:45 a.m. - 11:15 a.m. 2E411
Friday January 26th, 2024 - 9:45 a.m. - 11:15 a.m. 2E411
Wednesday January 31, 2024 - 9:45 a.m. - 11:15 a.m. 2F161 - Exam
Registration period: December 4th, 2023 to January 10th, 2024!!!
Information
Aims, contents and method of the course
Lipid-based applications of modern therapeutics. Production, characterization, application and approval of lipid-based nanoparticles. These include, for example, Doxil, Givosiran and Comirnaty. Principles are demonstrated in a practical part.
Assessment and permitted materials
Written exam - (Aids allowed: calculator)
Minimum requirements and assessment criteria
Active participation during the lecture (30%)
- questions, answersPractical course (30%)
- quiz (short multiple choice test)
- questions, answersExam (40%)
- 45 min written exam (in person, no open book)
- questions, answersPractical course (30%)
- quiz (short multiple choice test)
- questions, answersExam (40%)
- 45 min written exam (in person, no open book)
Examination topics
Fundamentals of lipids and formation of lipid nanoparticles in solution.
The importance of charge and size of lipid nanoparticles for the delivery of pharmaceuticals
Passive and active targeting
The formation and composition of a protein corona around lipid nanoparticles
The function of PEG during the formulation of lipid nanoparticles and their distribution in the body
The role of the EPR effect
The MPS system
Lipid nanoparticle formulation.
What are the endocytosis mechanisms and which are relevant for lipid nanoparticles?
How can the extracellular matrix influence the uptake of lipid nanoparticles?
Case study 1: DOXIL
Case study 2: ONPATTRO
Case study 3: mRNA COVID vaccines
The importance of charge and size of lipid nanoparticles for the delivery of pharmaceuticals
Passive and active targeting
The formation and composition of a protein corona around lipid nanoparticles
The function of PEG during the formulation of lipid nanoparticles and their distribution in the body
The role of the EPR effect
The MPS system
Lipid nanoparticle formulation.
What are the endocytosis mechanisms and which are relevant for lipid nanoparticles?
How can the extracellular matrix influence the uptake of lipid nanoparticles?
Case study 1: DOXIL
Case study 2: ONPATTRO
Case study 3: mRNA COVID vaccines
Reading list
Literature references will be given during the lecture for repetition of the content and further studies.
Association in the course directory
MA8, MA23
Last modified: Th 11.01.2024 12:06