323151 VU Fragment-based Drug Design - MPS10 (2025S)

The course provides insight into how fragment-based drug design can help in modern drug discovery. Concepts such as molecular complexity, additivity of binding energies and approaches for fragment evolution such as linking, merging, growing, will be discussed. Additionally, you will learn about fragment library design and methods for fragment screening.

The course will follow a flipped classroom approach and students are handed out the lecture slides plus videos prior to the in-person seminars. during the seminars we will discuss the content of the lecture. Hence, self-study of the material is a prerequisite for the successful participation. During the in-person seminars students will present papers that directly relate to the subjects of the lectures to further expand their understanding for the subject.