Universität Wien

530034 SE SE Advanced Algorithms in RNA Research (2023W)

2.00 ECTS (2.00 SWS), SPL 53 - Doktoratsstudium Chemie
Continuous assessment of course work

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

max. 15 participants
Language: German, English

Lecturers

Classes

we will set the exact dates for meeting mid October.


Information

Aims, contents and method of the course

Topic: new algorithmic developments in RNA secondary structure prediction.Levinthal's Paradox is the observation that hat finding the native folded state of a protein by a random search among all possible configurations can takes
an unfeasibly long time. Moreover, most computational models of protein
folding are known to be NP-hard, essentially excluding the existence for
an efficient short-cut that would serve ALL amino-acid sequences. The
solution of this conundrum is that evolution does not care about all
sequences, but only the subset that "make sense", in particular those that
find their groundstate with the algorithm at hand, namely an essentially local
"greedy" dynamics defined by physics. Goal of this year's course will to
develop an understanding the interplay algorithm, instance set, and
evolution using a simple RNA secondary model as example.

Assessment and permitted materials

Joint project to implement, test, and apply an algorithmic development

Minimum requirements and assessment criteria

Consistent active participation

Examination topics

N/A

Reading list

https://academic.oup.com/bioinformatics/article/22/5/614/205542

bitte github account anlegen und userid an mich emailen, damit ich die Teilnehmer einladen kann.

Association in the course directory

Doktorat, Freie Wahlfächer und Transferable Skills, BC-Wahl, CH-FE, EF1-3

Last modified: We 25.10.2023 13:28